Wasl - WASP like actin nucleation promoting factor Gene

Also Known as TRS4; N-WASP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 682507

Summary

Enables cytoskeletal protein binding activity and identical protein binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of cellular component organization; and postsynaptic actin Cytoskeleton organization. Located in Golgi membrane; cell leading edge; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]

Wasl Products (1)

mRNA Protein Name
NM_001110365.1 NP_001103835.1 actin nucleation-promoting factor WASL

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal protein binding IPI
IPI: Inferred from physical interaction
22797892 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9422512 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9422512 RGD
Biological Process GO Annotation Evidence References Source
involved in membrane invagination IDA
IDA: Inferred from direct assay
20730103 RGD
involved in plasma membrane tubulation IDA
IDA: Inferred from direct assay
20730103 RGD
involved in positive regulation of chemotaxis IMP
IMP: Inferred from mutant phenotype
19373774 RGD
involved in positive regulation of clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
20730103 RGD
involved in positive regulation of filopodium assembly IDA
IDA: Inferred from direct assay
20730103 RGD
involved in postsynapse organization EXP
EXP: Inferred from Experiment
18430734 RGD
involved in postsynapse organization IDA
IDA: Inferred from direct assay
18430734 RGD
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
18430734 RGD
involved in postsynaptic actin cytoskeleton organization EXP
EXP: Inferred from Experiment
18430734 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
18430734 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18430734 RGD
involved in regulation of cell projection assembly IMP
IMP: Inferred from mutant phenotype
19373774 RGD
involved in vesicle budding from membrane IDA
IDA: Inferred from direct assay
20730103 RGD
involved in vesicle organization IDA
IDA: Inferred from direct assay
20730103 RGD
involved in vesicle transport along actin filament IDA
IDA: Inferred from direct assay
20730103 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
15147909 RGD
located in cell leading edge IDA
IDA: Inferred from direct assay
20566646 RGD
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
20730103 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
18430734 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18430734 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18430734 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
18430734 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
18430734 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin nucleation-promoting factor WASL

neural Wiskott-Aldrich syndrome protein

  • Wiskott-Aldrich syndrome-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15747 WASL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wasl NCBI NCBI:8976