Wasl - WASP like actin nucleation promoting factor Gene

Rattus norvegicus

Also known as TRS4; N-WASP

Gene ID: 682507 | Gene type: protein coding

About Wasl

Summary

Enables cytoskeletal protein binding activity and identical protein binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of cellular component organization; and postsynaptic actin Cytoskeleton organization. Located in Golgi membrane; cell leading edge; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]

Wasl Products(1)

mRNA	Protein	Name
NM_001110365.1	NP_001103835.1	actin nucleation-promoting factor WASL

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	22797892	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9422512	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9422512	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in membrane invagination	IDA IDA: Inferred from direct assay	20730103	RGD
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	20730103	RGD
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	19373774	RGD
involved in positive regulation of clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	20730103	RGD
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	20730103	RGD
involved in postsynapse organization	EXP EXP: Inferred from Experiment	18430734	RGD
involved in postsynapse organization	IDA IDA: Inferred from direct assay	18430734	RGD
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	18430734	RGD
involved in postsynaptic actin cytoskeleton organization	EXP EXP: Inferred from Experiment	18430734	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	18430734	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18430734	RGD
involved in regulation of cell projection assembly	IMP IMP: Inferred from mutant phenotype	19373774	RGD
involved in vesicle budding from membrane	IDA IDA: Inferred from direct assay	20730103	RGD
involved in vesicle organization	IDA IDA: Inferred from direct assay	20730103	RGD
involved in vesicle transport along actin filament	IDA IDA: Inferred from direct assay	20730103	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	15147909	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	20566646	RGD
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	20730103	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	18430734	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18430734	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18430734	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	18430734	RGD
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	18430734	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

actin nucleation-promoting factor WASL

neural Wiskott-Aldrich syndrome protein

Wiskott-Aldrich syndrome-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15747	WASL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wasl	NCBI	NCBI:8976

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