Lrrtm2 - leucine rich repeat transmembrane neuronal 2 Gene

Rattus norvegicus

Gene ID: 685472 | Gene type: protein coding

About Lrrtm2

Summary

Enables neurexin family protein binding activity. Involved in regulation of postsynaptic density assembly. Acts upstream of or within synapse organization. Located in excitatory synapse. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic density membrane. Orthologous to human LRRTM2 (leucine rich repeat transmembrane neuronal 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrtm2 Products(1)

mRNA	Protein	Name
NM_001109469.1	NP_001102939.1	leucine-rich repeat transmembrane neuronal protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neurexin family protein binding	IPI IPI: Inferred from physical interaction	21424692	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	19285470	RGD
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	19285470	RGD
acts upstream of or within synapse organization	IDA IDA: Inferred from direct assay	19285470	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19285470	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	19285470	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19285470	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19285470	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19285470	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	19285470	RGD
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	19285470	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	19285470	RGD
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	19285470	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leucine-rich repeat transmembrane neuronal protein 2

leucine-rich repeat neuronal 2 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07842	LRRTM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrrtm2	NCBI	NCBI:26045

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