LRRTM2 - leucine rich repeat transmembrane neuronal 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26045

About LRRTM2

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,868,921-138,875,335 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues and 22 paralogues. Biased expression in brain (RPKM 12.7), placenta (RPKM 1.4) and 2 other tissues.

Summary

Predicted to enable neurexin family protein binding activity. Predicted to be involved in regulation of postsynaptic density assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]

LRRTM2 Products (1)

mRNA Protein Name
NM_015564.3 NP_056379.1 leucine-rich repeat transmembrane neuronal protein 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
27565350 GOA
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
27565350 GOA
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
27565350 GOA
is active in postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
27565350 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRTM2 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (110 - 169)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (182 - 221)

LRR_8

LRR_8: Leucine rich repeat (255 - 311)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 516 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat transmembrane neuronal protein 2

  • leucine-rich repeat neuronal 2 protein

LRRTM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRTM2 O43300 TNF Homo sapiens P01375
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRTM2 Proteins

Cat. No. Product Name Accession Purity
HY-P70203 LRRTM2 Protein, Human (HEK293, His) O43300 (C34-R422) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Histrionic Personality Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07842 LRRTM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRRTM2 RGD RGD:1593785
Mus musculus LRRTM2 MGD MGI:2389174
Bos taurus LRRTM2 VGNC VGNC:31043
Felis catus LRRTM2 VGNC VGNC:63315
Canis familiaris LRRTM2 VGNC VGNC:42830
Others LRRTM2 NCBI