LRRTM2 Protein, Human (HEK293, His)
The LRRTM2 protein is critical for developing and maintaining excitatory synapses, regulating AMPA receptor surface expression, and directing the formation of functional glutamate release sites for synaptic efficacy.LRRTM2 serves as a ligand for presynaptic receptors NRXN1-A and NRXN1-B and participates in transsynaptic signaling.LRRTM2 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The LRRTM2 protein is critical for developing and maintaining excitatory synapses, regulating AMPA receptor surface expression, and directing the formation of functional glutamate release sites for synaptic efficacy.LRRTM2 serves as a ligand for presynaptic receptors NRXN1-A and NRXN1-B and participates in transsynaptic signaling.LRRTM2 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM2 protein, expressed by HEK293 , with C-6*His labeled tag.
The LRRTM2 Protein plays a pivotal role in the development and maintenance of excitatory synapses within the vertebrate nervous system. Functioning as a key regulator, LRRTM2 modulates the surface expression of AMPA receptors and guides the formation of functional glutamate release sites, contributing to synaptic efficacy. Additionally, LRRTM2 acts as a ligand for presynaptic receptors NRXN1-A and NRXN1-B, suggesting its involvement in trans-synaptic signaling. This protein forms interactions with DLG4 and neurexin NRXN1, with the latter interaction mediated by heparan sulfate glycan modification on neurexin. The multifaceted interactions and regulatory functions of LRRTM2 highlight its integral role in orchestrating synaptic development and neurotransmission processes in the nervous system.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
O43300 (C34-R422)
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Molecular Construction
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N-term
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LRRTM2 (C34-R422)
Accession # O43300 -
6*His
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C-term
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Protein Length
Partial
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Synonyms
LRRTM2; Leucine-Rich Repeat Neuronal 2 Protein; Leucine Rich Repeat Transmembrane Neuronal 2; Leucine-Rich Repeat Transmembrane Neuronal 2 Protein; KIAA0416; LRRN2; Leucine-Rich Repeat Transmembrane Neuronal Protein 2
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AA Sequence
CPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQR
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Predicted Molecular Mass
45.6 kDa
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Molecular Weight
Approximately 74 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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