LRRTM2 Protein, Human (HEK293, His)

The LRRTM2 protein is critical for developing and maintaining excitatory synapses, regulating AMPA receptor surface expression, and directing the formation of functional glutamate release sites for synaptic efficacy. LRRTM2 serves as a ligand for presynaptic receptors NRXN1-A and NRXN1-B and participates in transsynaptic signaling. LRRTM2 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LRRTM2 Protein, Human (HEK293, His) is 389 a.a., with molecular weight of ~74.0 kDa.

The LRRTM2 Protein plays a pivotal role in the development and maintenance of excitatory synapses within the vertebrate nervous system. Functioning as a key regulator, LRRTM2 modulates the surface expression of AMPA receptors and guides the formation of functional glutamate release sites, contributing to synaptic efficacy. Additionally, LRRTM2 acts as a ligand for presynaptic receptors NRXN1-A and NRXN1-B, suggesting its involvement in trans-synaptic signaling. This protein forms interactions with DLG4 and neurexin NRXN1, with the latter interaction mediated by heparan sulfate glycan modification on neurexin. The multifaceted interactions and regulatory functions of LRRTM2 highlight its integral role in orchestrating synaptic development and neurotransmission processes in the nervous system.

Human

HEK293

C-6*His

O43300 (C34-R422)

26045  [NCBI]

CPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLCWNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFTQR

Approximately 74.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.