Sorbs1 - sorbin and SH3 domain containing 1 Gene
Also Known as CAP; SH3P12
Species: Rattus norvegicus
Gene Type: protein coding
Gene ID: 686098
Summary
Enables Insulin Receptor binding activity and ubiquitin protein Ligase binding activity. Involved in several processes, including response to activity; response to insulin; and response to monosodium L-glutamate. Located in plasma membrane. Part of Insulin Receptor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Sorbs1 Products (50)
| mRNA | Protein | Name |
|---|---|---|
| XM_039095072.1 | XP_038951000.1 | sorbin and SH3 domain-containing protein 1 isoform X5 |
| XM_039095057.1 | XP_038950985.1 | sorbin and SH3 domain-containing protein 1 isoform X2 |
| XM_039095066.1 | XP_038950994.1 | sorbin and SH3 domain-containing protein 1 isoform X5 |
| XM_039095038.1 | XP_038950966.1 | sorbin and SH3 domain-containing protein 1 isoform X2 |
| XM_039095076.1 | XP_038951004.1 | sorbin and SH3 domain-containing protein 1 isoform X6 |
| XM_039095068.1 | XP_038950996.1 | sorbin and SH3 domain-containing protein 1 isoform X5 |
| XM_039095062.1 | XP_038950990.1 | sorbin and SH3 domain-containing protein 1 isoform X3 |
| XM_039095058.1 | XP_038950986.1 | sorbin and SH3 domain-containing protein 1 isoform X2 |
| XM_039095065.1 | XP_038950993.1 | sorbin and SH3 domain-containing protein 1 isoform X4 |
| XM_039095048.1 | XP_038950976.1 | sorbin and SH3 domain-containing protein 1 isoform X2 |
| XM_039095059.1 | XP_038950987.1 | sorbin and SH3 domain-containing protein 1 isoform X2 |
| XM_039095040.1 | XP_038950968.1 | sorbin and SH3 domain-containing protein 1 isoform X2 |
| XM_039095037.1 | XP_038950965.1 | sorbin and SH3 domain-containing protein 1 isoform X1 |
| XM_039095089.1 | XP_038951017.1 | sorbin and SH3 domain-containing protein 1 isoform X9 |
| XM_039095080.1 | XP_038951008.1 | sorbin and SH3 domain-containing protein 1 isoform X7 |
| XM_039095095.1 | XP_038951023.1 | sorbin and SH3 domain-containing protein 1 isoform X11 |
| XM_039095092.1 | XP_038951020.1 | sorbin and SH3 domain-containing protein 1 isoform X10 |
| XM_039095084.1 | XP_038951012.1 | sorbin and SH3 domain-containing protein 1 isoform X8 |
| XM_039095099.1 | XP_038951027.1 | sorbin and SH3 domain-containing protein 1 isoform X12 |
| XM_039095115.1 | XP_038951043.1 | sorbin and SH3 domain-containing protein 1 isoform X14 |
| XM_039095107.1 | XP_038951035.1 | sorbin and SH3 domain-containing protein 1 isoform X13 |
| XM_039095125.1 | XP_038951053.1 | sorbin and SH3 domain-containing protein 1 isoform X15 |
| XM_039095135.1 | XP_038951063.1 | sorbin and SH3 domain-containing protein 1 isoform X16 |
| XM_039095239.1 | XP_038951167.1 | sorbin and SH3 domain-containing protein 1 isoform X43 |
| XM_039095225.1 | XP_038951153.1 | sorbin and SH3 domain-containing protein 1 isoform X37 |
| XM_039095185.1 | XP_038951113.1 | sorbin and SH3 domain-containing protein 1 isoform X26 |
| XM_039095140.1 | XP_038951068.1 | sorbin and SH3 domain-containing protein 1 isoform X18 |
| XM_039095194.1 | XP_038951122.1 | sorbin and SH3 domain-containing protein 1 isoform X29 |
| XM_039095212.1 | XP_038951140.1 | sorbin and SH3 domain-containing protein 1 isoform X32 |
| XM_039095232.1 | XP_038951160.1 | sorbin and SH3 domain-containing protein 1 isoform X42 |
| XM_039095158.1 | XP_038951086.1 | sorbin and SH3 domain-containing protein 1 isoform X22 |
| XM_039095189.1 | XP_038951117.1 | sorbin and SH3 domain-containing protein 1 isoform X28 |
| XM_039095147.1 | XP_038951075.1 | sorbin and SH3 domain-containing protein 1 isoform X19 |
| XM_039095156.1 | XP_038951084.1 | sorbin and SH3 domain-containing protein 1 isoform X21 |
| XM_039095229.1 | XP_038951157.1 | sorbin and SH3 domain-containing protein 1 isoform X40 |
| XM_039095226.1 | XP_038951154.1 | sorbin and SH3 domain-containing protein 1 isoform X38 |
| XM_039095228.1 | XP_038951156.1 | sorbin and SH3 domain-containing protein 1 isoform X39 |
| XM_039095161.1 | XP_038951089.1 | sorbin and SH3 domain-containing protein 1 isoform X23 |
| XM_039095154.1 | XP_038951082.1 | sorbin and SH3 domain-containing protein 1 isoform X20 |
| XM_039095169.1 | XP_038951097.1 | sorbin and SH3 domain-containing protein 1 isoform X24 |
| XM_039095231.1 | XP_038951159.1 | sorbin and SH3 domain-containing protein 1 isoform X41 |
| XM_039095216.1 | XP_038951144.1 | sorbin and SH3 domain-containing protein 1 isoform X33 |
| XM_039095180.1 | XP_038951108.1 | sorbin and SH3 domain-containing protein 1 isoform X25 |
| XM_039095188.1 | XP_038951116.1 | sorbin and SH3 domain-containing protein 1 isoform X27 |
| XM_039095196.1 | XP_038951124.1 | sorbin and SH3 domain-containing protein 1 isoform X30 |
| XM_039095220.1 | XP_038951148.1 | sorbin and SH3 domain-containing protein 1 isoform X34 |
| XM_039095223.1 | XP_038951151.1 | sorbin and SH3 domain-containing protein 1 isoform X36 |
| XM_039095221.1 | XP_038951149.1 | sorbin and SH3 domain-containing protein 1 isoform X35 |
| XM_039095139.1 | XP_038951067.1 | sorbin and SH3 domain-containing protein 1 isoform X17 |
| XM_039095206.1 | XP_038951134.1 | sorbin and SH3 domain-containing protein 1 isoform X31 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables insulin receptor binding |
IDA
IDA: Inferred from direct assay
|
14525909 | RGD |
| enables ubiquitin protein ligase binding |
IPI
IPI: Inferred from physical interaction
|
14525909 | RGD |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in response to L-glutamate |
IEP
IEP: Inferred from expression pattern
|
14525909 | RGD |
| involved in response to activity |
IEP
IEP: Inferred from expression pattern
|
18502271 | RGD |
| involved in response to insulin |
IEP
IEP: Inferred from expression pattern
|
14525909 | RGD |
| involved in response to lipid |
IEP
IEP: Inferred from expression pattern
|
18702941 | RGD |
| involved in response to starvation |
IEP
IEP: Inferred from expression pattern
|
14525909 | RGD |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of insulin receptor complex |
IDA
IDA: Inferred from direct assay
|
14525909 | RGD |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
sorbin and SH3 domain-containing protein 1 |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS13567 | SORBS1 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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