Mtcl1 - microtubule crosslinking factor 1 Gene

Also Known as Soga2; Ccdc165; Kiaa0802; t8219b25; mKIAA0802; D130071O13; 1110012J17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68617

Summary

Enables microtubule binding activity and protein homodimerization activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity; microtubule bundle formation; and positive regulation of protein targeting to membrane. Located in several cellular components, including apicolateral plasma membrane; cytoskeleton; and lateral plasma membrane. Is expressed in several structures, including alimentary system; cranial ganglion; limb segment; metanephros; and neural ectoderm. Orthologous to human MTCL1 (microtubule crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mtcl1 Products (2)

mRNA Protein Name
NM_001114098.2 NP_001107570.1 microtubule cross-linking factor 1 isoform 1
NM_172963.4 NP_766551.3 microtubule cross-linking factor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
23902687 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23902687 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
23902687 MGI
Biological Process GO Annotation Evidence References Source
involved in establishment or maintenance of epithelial cell apical/basal polarity IDA
IDA: Inferred from direct assay
23902687 MGI
involved in microtubule bundle formation IDA
IDA: Inferred from direct assay
23902687 MGI
involved in positive regulation of protein targeting to membrane IDA
IDA: Inferred from direct assay
23902687 MGI
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
23902687 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
23902687 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
23902687 MGI
located in microtubule bundle IDA
IDA: Inferred from direct assay
23902687 MGI
located in midbody IDA
IDA: Inferred from direct assay
23902687 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
23902687 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule cross-linking factor 1

  • PAR-1-interacting protein

  • SOGA family member 2

  • coiled-coil domain-containing protein 165

  • protein SOGA2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08756 MTCL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22652 Mtcl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtcl1 NCBI NCBI:23255