Trim37 - tripartite motif-containing 37 Gene

Also Known as MUL; TEF3; 1110032A10Rik; 2810004E07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68729

Summary

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which is typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. In mouse this protein is proposed to oligomerize through its coiled coil domain and has been reported to be expressed in neural crest-derived tissues as well as in tissues whose development is regulated by mesenchymal-epithelial interactions. In humans, mutations in this gene are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder characterized by prenatal onset growth failure, cardiomyopathy and dysmorphic features. [provided by RefSeq, Jan 2013]

Trim37 Products (5)

mRNA Protein Name
NM_001363025.1 NP_001349954.1 E3 ubiquitin-protein ligase TRIM37 isoform 1
NM_001363026.1 NP_001349955.1 E3 ubiquitin-protein ligase TRIM37 isoform 3
NM_001363027.1 NP_001349956.1 E3 ubiquitin-protein ligase TRIM37 isoform 4
NM_001363028.1 NP_001349957.1 E3 ubiquitin-protein ligase TRIM37 isoform 5
NM_197987.2 NP_932104.1 E3 ubiquitin-protein ligase TRIM37 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
24105743 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
25470042 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM37

  • RING-type E3 ubiquitin transferase TRIM37

  • TRAF encompassing factor 3

  • tripartite motif-containing protein 37

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-172737 RP-1664 Inhibitor 98.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15041 TRIM37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim37 NCBI NCBI:4591