Fendrr - Foxf1 adjacent non-coding developmental regulatory RNA Gene

Also Known as LL66; lincFoxf1; linc-Foxf1a; 1110050K14Rik

Species: Mus musculus

Gene Type: ncRNA
Gene ID: 68790

Summary

This gene encodes a spliced long non-coding RNA transcribed from a bidirectional promoter shared with Foxf1 on the opposite strand. The encoded transcript is essential for normal development of the heart and body wall. It is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It plays a role in cell fate determination in tissues derived from the lateral plate mesoderm. Knockout models reveal loss of this gene is lethal in mice. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23369715 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromatin organization IMP
IMP: Inferred from mutant phenotype
23369715 MGI
acts upstream of or within embryonic lung development IMP
IMP: Inferred from mutant phenotype
25909911 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
24381249 MGI
involved in in utero embryonic development IMP
IMP: Inferred from mutant phenotype
25909911 MGI
acts upstream of or within lateral mesoderm development IMP
IMP: Inferred from mutant phenotype
23369715 MGI
involved in lung development IMP
IMP: Inferred from mutant phenotype
25909911 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
25909911 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
24381249 MGI
acts upstream of or within respiratory system development IMP
IMP: Inferred from mutant phenotype
25909911 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Orthologs Information

Species Symbol Source ID
Homo sapiens Fendrr NCBI NCBI:400550