Spx - spexin hormone Gene

Also Known as Npq

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 691138

Summary

Predicted to enable neuropeptide hormone activity; type 2 Galanin receptor binding activity; and type 3 Galanin receptor binding activity. Involved in several processes, including long-chain fatty acid import into cell; negative regulation of appetite; and negative regulation of renal sodium excretion. Located in cytoplasm. Orthologous to human SPX (spexin hormone). [provided by Alliance of Genome Resources, Apr 2022]

Spx Products (1)

mRNA Protein Name
NM_001083933.3 NP_001077402.2 spexin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in long-chain fatty acid import into cell IDA
IDA: Inferred from direct assay
24550067 RGD
involved in negative regulation of appetite IDA
IDA: Inferred from direct assay
24550067 RGD
involved in negative regulation of heart rate IDA
IDA: Inferred from direct assay
22038051 RGD
involved in negative regulation of renal sodium excretion IDA
IDA: Inferred from direct assay
22038051 RGD
involved in positive regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
22038051 RGD
involved in regulation of sensory perception of pain IDA
IDA: Inferred from direct assay
22038051 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20530460 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spexin

  • LRRGT00060

  • liver regeneration-related protein LRRGT00060

  • neuropeptide Q

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P5931 Spinoxin Inhibitor 98.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13741 SPX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992508 SPX-101 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spx NCBI NCBI:80763