Cox10 - heme A:farnesyltransferase cytochrome c oxidase assembly factor 10 Gene

Also Known as 2410004F01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70383

Summary

Predicted to enable farnesyltranstransferase activity. Acts upstream of or within several processes, including cytochrome complex assembly; heme A biosynthetic process; and mitochondrial fission. Located in mitochondrion. Is expressed in alimentary system; nervous system; and respiratory system. Used to study Parkinson's disease; cytochrome-c oxidase deficiency disease; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2022]

Cox10 Products (1)

mRNA Protein Name
NM_178379.3 NP_848466.1 protoheme IX farnesyltransferase, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protoheme IX farnesyltransferase activity IMP
IMP: Inferred from mutant phenotype
16782876 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aerobic respiration IMP
IMP: Inferred from mutant phenotype
16782876 MGI
acts upstream of or within copper ion homeostasis IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within cytochrome complex assembly IDA
IDA: Inferred from direct assay
16103131 MGI
acts upstream of or within heme A biosynthetic process IDA
IDA: Inferred from direct assay
16103131 MGI
involved in heme A biosynthetic process IGI
IGI: Inferred from genetic interaction
12928484 MGI
acts upstream of or within heme A biosynthetic process IMP
IMP: Inferred from mutant phenotype
16782876 MGI
involved in heme O biosynthetic process IGI
IGI: Inferred from genetic interaction
12928484 MGI
acts upstream of or within leukocyte differentiation IMP
IMP: Inferred from mutant phenotype
36301669 MGI
acts upstream of or within mitochondrial fission IMP
IMP: Inferred from mutant phenotype
16103131 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
16782876 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
36301669 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
16103131 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16103131 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protoheme IX farnesyltransferase, mitochondrial

  • COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase

  • cytochrome c oxidase assembly protein 10

  • heme O synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03056 COX10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20891 Cox10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27408 Cox10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cox10 NCBI NCBI:1352