Zdhhc2 - zinc finger, DHHC domain containing 2 Gene

Also Known as DHHC-2; 5730415P04Rik; 6430583A19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 70546

Summary

Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation and protein localization to plasma membrane. Acts upstream of or within protein palmitoylation. Located in plasma membrane; postsynaptic recycling endosome; and recycling endosome membrane. Is integral component of plasma membrane. Is expressed in several structures, including early conceptus; genitourinary system; nervous system; pancreas tip epithelium; and retina. Orthologous to human ZDHHC2 (zinc finger DHHC-type palmitoyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Zdhhc2 Products (2)

mRNA	Protein	Name
NM_001357249.1	NP_001344178.1	palmitoyltransferase ZDHHC2 isoform 2
NM_178395.4	NP_848482.1	palmitoyltransferase ZDHHC2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	15603741	MGI
enables protein-cysteine S-myristoyltransferase activity	IDA IDA: Inferred from direct assay	28167757	MGI
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	28167757	MGI
enables protein-cysteine S-palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	25589740	MGI
enables protein-cysteine S-stearoyltransferase activity	IDA IDA: Inferred from direct assay	28167757	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: Inferred from direct assay	25589740	MGI
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	21343290	MGI
involved in protein localization to membrane raft	IMP IMP: Inferred from mutant phenotype	25589740	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21343290	MGI
acts upstream of or within protein palmitoylation	IDA IDA: Inferred from direct assay	15603741	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	25589740	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21343290	MGI
is active in postsynaptic recycling endosome	IDA IDA: Inferred from direct assay	25589740	MGI
located in postsynaptic recycling endosome	IDA IDA: Inferred from direct assay	25589740	MGI
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	21471008	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
palmitoyltransferase ZDHHC2	acyltransferase ZDHHC2 zinc finger DHHC domain-containing protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16019	ZDHHC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zdhhc2	NCBI	NCBI:51201