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ZAN - zonadhesin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7455

About ZAN

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,733,595-100,797,797 (from NCBI)

This gene has 8 transcripts (splice variants), 147 orthologues and 19 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

ZAN Products (2)

mRNA	Protein	Name
NM_003386.3	NP_003377.2	zonadhesin isoform 3 precursor
NM_173059.3	NP_775082.2	zonadhesin isoform 6 precursor

ZAN Protein Structure

MAM

TIL

TILa

VWD

TIL

TILa

VWD

TIL

TILa

VWD

TIL

TILa

VWD

EGF

0
500
1000
1500
2000
2500
2720 a.a.

Protein Preferred Names	Protein Names
zonadhesin

Related Diseases

Diseases	Alias
Granulomatous Orchitis	Non-Specific Granulomatous Orchitis
Deafness, Autosomal Recessive 21	DFNB21 Autosomal Recessive Nonsyndromic Deafness 21 Autosomal Recessive Deafness 21 Deafness, Autosomal Recessive, 21 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 21 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 21 Deafness, Autosomal Recessive, Type 21
Von Willebrand Disease, Type 2	Von Willebrand Disease Type 2m Von Willebrand Disease Type 2 Von Willebrand Disease Type 2a Von Willebrand Disease Type 2b Von Willebrand Disease Type 2n VWD2 Von Willebrand'S Disease 2 Von Willebrand Disease Type Ii Von Willebrand Disease, Type Ii Vwd, Type 2 Von Willebrand Disease, Types 2a, 2b, 2m, And 2n Vwd Type 2 Von Willebrand Disease 2 Von Willebrand Disease Normandy Variant Von Willebrand Disease Type 2 Malmo Von Willebrand Disease Type I New York Von Willebrand Factor Deficiency Type 2 Vwd2a Vwd2b Vwd2m Vwd2n Von Willebrand Disease, Type 2a, 2b, 2m, And 2n Von Willebrand Disease, Type 2a Von Willebrand Disease, Type 2b Von Willebrand Disease, Type 2n
Deafness, Autosomal Dominant 13	DFNA13 Autosomal Dominant Nonsyndromic Deafness 13 Autosomal Dominant Deafness 13 Deafness, Autosomal Dominant, 13 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 13 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 13 Deafness, Autosomal Dominant, Type 13
Deafness, Autosomal Dominant 44	DFNA44 Autosomal Dominant Nonsyndromic Deafness 44 Autosomal Dominant Deafness 44 Deafness, Autosomal Dominant, 44 Deafness, Autosomal Dominant, Type 44
Von Willebrand Disease, Type 1	Von Willebrand Disease Type 1 VWD1 Von Willebrand'S Disease 1 Von Willebrand Disease Type I Von Willebrand Disease, Type I Vwd, Type 1 Vwd Type 1 Von Willebrand Disease 1 Von Willebrand Factor Deficiency Type 1 Von Willebrand Disease, Type 1, Susceptibility To
Von Willebrand Disease, Type 3	Von Willebrand Disease Type 3 VWD3 Von Willebrand'S Disease 3 Von Willebrand Disease Type Iii Von Willebrand Disease, Type Iii Vwd, Type 3 Vwd Type 3 Von Willebrand Disease 3 Von Willebrand Disease Recessive Form Von Willebrand Factor Deficiency Type 3
Orchitis	Inflammation Of Testis Orchititis Mumps Orchitis
Tick Paralysis
Epididymo-Orchitis
Deafness, Autosomal Dominant 10	DFNA10 Autosomal Dominant Nonsyndromic Deafness 10 Autosomal Dominant Deafness 10 Deafness, Autosomal Dominant, 10 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 10 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 10 Deafness, Autosomal Dominant, Type 10
Autosomal Recessive Nonsyndromic Deafness	Deafness, Autosomal Recessive, Nonsyndromic
Autosomal Dominant Nonsyndromic Deafness	Autosomal Dominant Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15950	ZAN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZAN	RGD	RGD:1305044
Macaca mulatta	ZAN	VGNC	VGNC:81797
Bos taurus	ZAN	VGNC	VGNC:99806
Felis catus	ZAN	VGNC	VGNC:80703
Mus musculus	ZAN	MGD	MGI:106656
Others	ZAN	NCBI