MANF - mesencephalic astrocyte derived neurotrophic factor Gene

Also Known as ARP; ARMET

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7873

About MANF

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,385,291-51,389,397 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 71.3), appendix (RPKM 44.4) and 25 other tissues.

Summary

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

MANF Products (1)

mRNA Protein Name
NM_006010.6 NP_006001.5 mesencephalic astrocyte-derived neurotrophic factor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25543119 GOA
enables sulfatide binding IPI
IPI: Inferred from physical interaction
29497057 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
29497057 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
29497057 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MANF Protein Structure

Armet

Armet: Degradation arginine-rich protein for mis-folding (29 - 182)

  • 0
  • 100
  • 182 a.a.
Protein Preferred Names Protein Names

mesencephalic astrocyte-derived neurotrophic factor

  • arginine-rich, mutated in early stage tumors

MANF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MANF P55145 RTN1 Homo sapiens Q16799-3
Pull Down
25543119
Intra
MANF P55145 RTN1 Homo sapiens Q16799-3
Y2H
25543119
Intra
MANF P55145 RTN1 Homo sapiens Q16799-3
Anti Tag CoIP
25543119
Intra
MANF P55145 BCL2L15 Homo sapiens Q5TBC7
Anti Tag CoIP
33961781
Intra
MANF P55145 BCL2L15 Homo sapiens Q5TBC7
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MANF Proteins

Cat. No. Product Name Accession Purity
HY-P7605 ARMET/MANF Protein, Human (HEK293, His) P55145 (L25-L182) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76731 ARMET/MANF Protein, Human (HEK293, Fc) A8K878 (L28-L185) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P71940A ARMET/MANF Protein, Human (His) P55145 (L25-L182) ≥ 95%, as determined by reducing SDS-PAGE.

MANF Antibodies

Cat. No. Product Name Application Reactivity
HY-P811306 ARMET Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Multiple Epiphyseal Dysplasia

  • Med

  • Polyepiphyseal Dysplasia

  • Edm

  • Epiphyseal Dysplasia, Multiple, 1

  • Epiphyseal Dysplasia, Multiple, 2

  • Epiphyseal Dysplasia, Multiple, 3

  • Epiphyseal Dysplasia, Multiple, 4

  • Epiphyseal Dysplasia, Multiple, 5

  • Epiphyseal Dysplasia, Multiple

  • Edm1

  • Edm2

  • Edm3

  • Edm4

  • Edm5

  • Epiphyseal Dysplasia, Fairbank Type

  • Epiphyseal Dysplasia, Ribbing Type

  • Multiple Epiphyseal Dysplasia, Autosomal Dominant

  • Multiple Epiphyseal Dysplasia, Autosomal Recessive

  • Rmed

  • Dysplasia, Epiphyseal, Multiple

  • Osteochondrodysplasias
Wolfram Syndrome 2

  • WFS2
Wolfram Syndrome

  • Didmoad Syndrome

  • Didmoad

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Wfs

  • Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

  • Didmoadud

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

  • Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08017 MANF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18040 Manf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24514 Manf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MANF VGNC VGNC:31171
Felis catus MANF VGNC VGNC:80621
Canis familiaris MANF VGNC VGNC:42951
Mus musculus MANF MGD MGI:1922090
Rattus norvegicus MANF RGD RGD:1307252
Macaca mulatta MANF VGNC VGNC:110354
Others MANF NCBI