MANF - mesencephalic astrocyte derived neurotrophic factor Gene

Homo sapiens

Also known as ARP; ARMET

Gene ID: 7873 | Gene type: protein coding

About MANF

Cytogenetic location: 3p21.2 Genomic coordinates (GRCh38): 3:51,385,291-51,389,397 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 71.3), appendix (RPKM 44.4) and 25 other tissues.

Summary

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

MANF Products(1)

mRNA	Protein	Name
NM_006010.6	NP_006001.5	mesencephalic astrocyte-derived neurotrophic factor precursor

MANF Protein Structure

Armet

0
100
182 a.a.

Protein Preferred Names

Protein Names

mesencephalic astrocyte-derived neurotrophic factor

arginine-rich, mutated in early stage tumors

Recombinant MANF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7605	ARMET/MANF Protein, Human (158a.a, HEK293, His)	P55145 (L25-L182)	≥95%
HY-P71940	ARMET/MANF Protein, Human	P55145 (L25-L182)	≥95%
HY-P76731	ARMET/MANF Protein, Human (HEK293, Fc)	A8K878 (M1-L182)	≥95%
HY-P76732	ARMET/MANF Protein, Human (182a.a, HEK293, His)	A8K878 (M1-L182)	≥95%
HY-P71940A	ARMET/MANF Protein, Human (His)	P55145 (L25-L182)	≥95%

Related Diseases

Diseases

Alias

Multiple Epiphyseal Dysplasia

Med	Polyepiphyseal Dysplasia
Edm	Epiphyseal Dysplasia, Multiple, 1
Epiphyseal Dysplasia, Multiple, 2	Epiphyseal Dysplasia, Multiple, 3
Epiphyseal Dysplasia, Multiple, 4	Epiphyseal Dysplasia, Multiple, 5
Epiphyseal Dysplasia, Multiple	Edm1
Edm2	Edm3
Edm4	Edm5
Epiphyseal Dysplasia, Fairbank Type	Epiphyseal Dysplasia, Ribbing Type
Multiple Epiphyseal Dysplasia, Autosomal Dominant	Multiple Epiphyseal Dysplasia, Autosomal Recessive
Rmed	Dysplasia, Epiphyseal, Multiple
Osteochondrodysplasias

Wolfram Syndrome 2

WFS2

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08017	MANF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MANF	VGNC	VGNC:31171
Felis catus	MANF	VGNC	VGNC:80621
Canis familiaris	MANF	VGNC	VGNC:42951
Mus musculus	MANF	MGD	MGI:1922090
Rattus norvegicus	MANF	RGD	RGD:1307252
Macaca mulatta	MANF	VGNC	VGNC:110354
Others	MANF	NCBI