SLBP - stem-loop binding protein Gene

Homo sapiens

Also known as HBP

Gene ID: 7884 | Gene type: protein coding

About SLBP

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,692,731-1,712,319 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 30.6), bone marrow (RPKM 27.2) and 25 other tissues.

Summary

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]

SLBP Products(3)

mRNA	Protein	Name
NM_001306074.2	NP_001293003.1	histone RNA hairpin-binding protein isoform 2
NM_001306075.2	NP_001293004.1	histone RNA hairpin-binding protein isoform 3
NM_006527.4	NP_006518.1	histone RNA hairpin-binding protein isoform 1

SLBP Protein Structure

SLBP_RNA_bind

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

histone RNA hairpin-binding protein

hairpin binding protein, histone

Related Diseases

Diseases

Alias

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Chromosome 2q31.2 Deletion Syndrome

Blepharochalasis

Dermatolysis Palpebrarum

Adiposa Ptosis

Epiphyseal Dysplasia, Multiple, 2

EDM2	Multiple Epiphyseal Dysplasia 2
Dysplasia, Epiphyseal, Multiple, Type 2

Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12984	SLBP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLBP	VGNC	VGNC:46210
Macaca mulatta	SLBP	VGNC	VGNC:77379
Rattus norvegicus	SLBP	RGD	RGD:1584682
Felis catus	SLBP	VGNC	VGNC:65179
Bos taurus	SLBP	VGNC	VGNC:34658
Mus musculus	SLBP	MGD	MGI:108402