SUGCT - succinyl-CoA:glutarate-CoA transferase Gene

Also Known as GA3; ORF19; DERP13; C7orf10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79783

About SUGCT

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:40,135,005-41,038,816 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.4), liver (RPKM 1.2) and 12 other tissues.

Summary

This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

SUGCT Products (4)

mRNA Protein Name
NM_001193311.2 NP_001180240.2 succinate--hydroxymethylglutarate CoA-transferase isoform 1
NM_001193312.2 NP_001180241.2 succinate--hydroxymethylglutarate CoA-transferase isoform 2
NM_001193313.2 NP_001180242.2 succinate--hydroxymethylglutarate CoA-transferase isoform 3
NM_024728.3 NP_079004.2 succinate--hydroxymethylglutarate CoA-transferase isoform 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables succinate-hydroxymethylglutarate CoA-transferase activity IDA
IDA: Inferred from direct assay
23893049 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
23893049 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUGCT Protein Structure

CoA_transf_3

CoA_transf_3: CoA-transferase family III (113 - 299)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

succinate--hydroxymethylglutarate CoA-transferase

  • Russel-Silver syndrome candidate

Related Diseases

Diseases Alias
Glutaric Aciduria Iii

  • Glutaryl-Coa Oxidase Deficiency

  • Ga Iii

  • Glutaric Acidemia Type 3

  • GA3

  • Glutaric Aciduria Type 3

  • Glutaric Aciduria 3

  • Glutaric Acidemia Type Iii

  • Glutaric Aciduria Type Iii
Trichothiodystrophy

  • Ttd

  • Amish Brittle Hair Syndrome

  • Bids Syndrome

  • Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

  • Ibids

  • Pibids

  • Trichothiodystrophy Syndromes
Robinow Syndrome, Autosomal Dominant 3

  • Autosomal Dominant Robinow Syndrome 3

  • DRS3

  • Robinow, Autosomal Dominant Syndrome, Type 3
Desmoid Disease, Hereditary

  • Fif

  • DESMD

  • Hereditary Desmoid Disease

  • Familial Infiltrative Fibromatosis

  • Fibromatosis, Familial Infiltrative

  • Fibromatosis, Aggressive
Amyotrophic Lateral Sclerosis 4, Juvenile

  • Amyotrophic Lateral Sclerosis Type 4

  • ALS4

  • Amyotrophic Lateral Sclerosis 4

  • Dhmn With Upper Motor Neuron Signs

  • Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs

  • Neuronopathy, Distal Hereditary Motor, With Pyramidal Features

  • Als 4

  • Distal Hereditary Motor Neuropathy With Pyramidal Features

  • Amyotrophic Lateral Sclerosis Juvenile 4

  • Neuronopathy Distal Hereditary Motor With Pyramidal Features

  • Sclerosis, Lateral, Amyotrophic, Type Type 4
Amyotrophic Lateral Sclerosis Type 6

  • Amyotrophic Lateral Sclerosis 6, Autosomal Recessive

  • Als6

  • Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia

  • Autosomal Recessive Amyotrophic Lateral Sclerosis 6

  • Sclerosis, Lateral, Amyotrophic, Type Type 6

  • Amyotrophic Lateral Sclerosis 6
Nephronophthisis 3

  • NPHP3

  • Nph3

  • Adolescent Nephronophthisis

  • Nephronophthisis, Type 3
Glutaric Acidemia I

  • Glutaryl-Coa Dehydrogenase Deficiency

  • GA1

  • Glutaric Acidemia Type 1

  • Glutaric Aciduria 1

  • Glutaric Aciduria Type 1

  • Glutaric Acidemia Type I

  • Glutaric Aciduria, Type 1

  • Glutaric Aciduria I

  • Ga I

  • Glutaricaciduria, Type I

  • Glutaryl-Coenzyme A Dehydrogenase Deficiency

  • Glutaric Academia Type 1

  • Glutaric Aciduria Type I

  • Ga-1

  • Gcdh Deficiency

  • Ga 1

  • Glutaric Acidemia 1

  • Gcdhd

  • Glutaric Aciduria, Type I

  • Glutaricaciduria I

  • Ga-I

  • Glutaricaciduria, Type 1
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W014125 Undecanedioic acid 98.0% Unkown
HY-RS14008 SUGCT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SUGCT MGD MGI:1923221
Rattus norvegicus SUGCT RGD RGD:1308114
Macaca mulatta SUGCT VGNC VGNC:81767
Bos taurus SUGCT VGNC VGNC:35462
Canis familiaris SUGCT VGNC VGNC:52052
Felis catus SUGCT VGNC VGNC:80727
Others SUGCT NCBI