KDM7A - lysine demethylase 7A Gene

Also Known as JHDM1D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80853

About KDM7A

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,084,746-140,176,983 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 9.6), colon (RPKM 7.1) and 25 other tissues.

Summary

Enables Histone Demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in histone lysine demethylation. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM7A Products (1)

mRNA Protein Name
NM_030647.2 NP_085150.1 lysine-specific demethylase 7A

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables 2-oxoglutarate-dependent dioxygenase activity IDA
IDA: Inferred from direct assay
20023638 GOA
enables histone H3K27me2/H3K27me3 demethylase activity IDA
IDA: Inferred from direct assay
20023638 GOA
enables histone H3K36 demethylase activity IDA
IDA: Inferred from direct assay
20622853 GOA
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
20023638 GOA
enables histone H4K20 demethylase activity IDA
IDA: Inferred from direct assay
20622853 GOA
enables iron ion binding IDA
IDA: Inferred from direct assay
20023638 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
20023638 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
20023638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM7A Protein Structure

PHD

PHD: PHD-finger (39 - 86)

JmjC

JmjC: JmjC domain, hydroxylase (269 - 369)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 941 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 7A

  • [histone H3]-dimethyl-L-lysine9 demethylase 7A

Related Diseases

Diseases Alias
Syndromic X-Linked Intellectual Disability Siderius Type

  • Mrxssd

  • Siderius-Hamel Syndrome

  • Siderius X-Linked Mental Retardation Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107573 KDM2/7-IN-1 Inhibitor 99.9% Unkown
HY-RS07224 KDM7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19701 Kdm7a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26196 Kdm7a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KDM7A VGNC VGNC:63074
Canis familiaris KDM7A VGNC VGNC:51806
Rattus norvegicus KDM7A RGD RGD:1592650
Mus musculus KDM7A MGD MGI:2443388
Bos taurus KDM7A VGNC VGNC:30533
Macaca mulatta KDM7A VGNC VGNC:73886
Others KDM7A NCBI