FZD9 - frizzled class receptor 9 Gene

Also Known as FZD3; CD349

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8326

About FZD9

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:73,433,778-73,436,120 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 15 paralogues.

Summary

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]

FZD9 Products (1)

mRNA	Protein	Name
NM_003508.3	NP_003499.1	frizzled-9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	19038973	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14688793	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	27509850	GOA
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	27509850	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27509850	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	20458727	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19038973	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19038973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD9 Protein Structure

Fz

Frizzled

0
100
200
300
400
500
591 a.a.

Protein Preferred Names	Protein Names
frizzled-9	frizzled 9, seven transmembrane spanning receptor

FZD9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82185	Frizzled 9 Antibody (YA1930)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Osteopathia Striata With Cranial Sclerosis	Hyperostosis Generalisata With Striations Robinow-Unger Syndrome OSCS Osteopathia Striata Cranial Sclerosis Osteopathia Striata-Cranial Sclerosis Syndrome Horan-Beighton Syndrome Os-Cs Osteopathia Striata - Cranial Sclerosis Voorhoeve Disease Osc
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05185	FZD9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21344	Fzd9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27863	Fzd9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FZD9	VGNC	VGNC:62407
Macaca mulatta	FZD9	VGNC	VGNC:81313
Canis familiaris	FZD9	VGNC	VGNC:41035
Bos taurus	FZD9	VGNC	VGNC:29172
Mus musculus	FZD9	MGD	MGI:1313278
Rattus norvegicus	FZD9	RGD	RGD:628817
Others	FZD9	NCBI