USP26 - ubiquitin specific peptidase 26 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83844

About USP26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:133,023,168-133,097,109 (from NCBI)

This gene has 3 transcripts (splice variants), 15 orthologues and 71 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

USP26 Products (1)

mRNA	Protein	Name
NM_031907.3	NP_114113.1	ubiquitin carboxyl-terminal hydrolase 26

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	28839133	GOA
enables deubiquitinase activity	IDA IDA: Inferred from direct assay	20501646	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20501646	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	28839133	GOA
involved in regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20501646	GOA
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	34202084	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20501646	GOA
located in sperm flagellum	IMP IMP: Inferred from mutant phenotype	34202084	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP26 Protein Structure

UCH

0
200
400
600
800
913 a.a.

Protein Preferred Names	Protein Names
ubiquitin carboxyl-terminal hydrolase 26	deubiquitinating enzyme 26

Related Diseases

Diseases	Alias
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Infertility
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Tonne-Kalscheuer Syndrome	TOKAS Mrx61 Intellectual Developmental Disorder With Or Without Hand And Foot Anomalies, Genital Anomalies, Or Congenital Diaphragmatic Hernia Mental Retardation, X-Linked 61 X-Linked Mental Retardation 61
Benign Pleural Mesothelioma	Mesothelioma Of Pleura Benign Neoplasm Of Mesothelial Tissue Of Pleura Pleural Malignant Mesothelioma
Acquired Hyperkeratosis	Acquired Keratoderma Keratoderma - Acquired Keratoderma, Acquired Keratosis Blennorrhagica
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Oligospermia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15536	USP26 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20127	Usp26 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26631	Usp26 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	USP26	RGD	RGD:1563443
Bos taurus	USP26	VGNC	VGNC:36719
Canis familiaris	USP26	VGNC	VGNC:48185
Mus musculus	USP26	MGD	MGI:1933247