SNX25 - sorting nexin 25 Gene

Also Known as SBBI31; MSTP043

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83891

About SNX25

This gene has 8 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in lung (RPKM 10.3), thyroid (RPKM 5.9) and 24 other tissues.

Summary

Predicted to enable type I transforming growth factor beta receptor binding activity. Involved in negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; and receptor catabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

SNX25 Products (9)

mRNA	Protein	Name
NM_001317781.2	NP_001304710.1	sorting nexin-25 isoform 6
NM_001378032.2	NP_001364961.1	sorting nexin-25 isoform 1
NM_001378034.2	NP_001364963.1	sorting nexin-25 isoform 2
NM_001378035.2	NP_001364964.1	sorting nexin-25 isoform 3
NM_001378036.2	NP_001364965.1	sorting nexin-25 isoform 4
NM_001378037.2	NP_001364966.1	sorting nexin-25 isoform 5
NM_001378038.2	NP_001364967.1	sorting nexin-25 isoform 7
NM_001378039.2	NP_001364968.1	sorting nexin-25 isoform 8
NM_001378040.2	NP_001364969.1	sorting nexin-25 isoform 9

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21266196	GOA
involved in receptor catabolic process	IMP IMP: Inferred from mutant phenotype	21266196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX25 Protein Structure

PXA

RGS

PX

Nexin_C

0
200
400
600
800
840 a.a.

Protein Preferred Names	Protein Names
sorting nexin-25

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive 20	Autosomal Recessive Spinocerebellar Ataxia 20 SCAR20 Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypotrophy Syndrome Autosomal Recessive Spinocerebellar Ataxia Type 20 Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypoplasia Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 20 Ataxia, Spinocerebellar, Autosomal Recessive, Type 20
Intellectual Developmental Disorder, Autosomal Dominant 38	Psychomotor Retardation, Epilepsy, And Language Disability Syndrome MRD38 Prelds Autosomal Dominant Non-Syndromic Intellectual Disability 38 Mental Retardation, Autosomal Dominant 38 Autosomal Dominant Intellectual Developmental Disorder 38 Autosomal Dominant Mental Retardation 38 Mental Retardation, Autosomal Dominant, Type 38

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13536	SNX25 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX25	RGD	RGD:1310150
Macaca mulatta	SNX25	VGNC	VGNC:77757
Canis familiaris	SNX25	VGNC	VGNC:46633
Mus musculus	SNX25	MGD	MGI:2142610
Bos taurus	SNX25	VGNC	VGNC:35104
Felis catus	SNX25	VGNC	VGNC:65552