SNX25 - sorting nexin 25 Gene

Homo sapiens

Also known as SBBI31; MSTP043

Gene ID: 83891 | Gene type: protein coding

About SNX25

This gene has 8 transcripts (splice variants), 209 orthologues and 3 paralogues. Broad expression in lung (RPKM 10.3), thyroid (RPKM 5.9) and 24 other tissues.

Summary

Predicted to enable type I transforming growth factor beta receptor binding activity. Involved in negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; and receptor catabolic process. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]

SNX25 Products(9)

mRNA	Protein	Name
NM_001317781.2	NP_001304710.1	sorting nexin-25 isoform 6
NM_001378032.2	NP_001364961.1	sorting nexin-25 isoform 1
NM_001378034.2	NP_001364963.1	sorting nexin-25 isoform 2
NM_001378035.2	NP_001364964.1	sorting nexin-25 isoform 3
NM_001378036.2	NP_001364965.1	sorting nexin-25 isoform 4
NM_001378037.2	NP_001364966.1	sorting nexin-25 isoform 5
NM_001378038.2	NP_001364967.1	sorting nexin-25 isoform 7
NM_001378039.2	NP_001364968.1	sorting nexin-25 isoform 8
NM_001378040.2	NP_001364969.1	sorting nexin-25 isoform 9

SNX25 Protein Structure

PXA

RGS

Nexin_C

0
200
400
600
840 a.a.

Protein Preferred Names

Protein Names

sorting nexin-25

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 20

Autosomal Recessive Spinocerebellar Ataxia 20	SCAR20
Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypotrophy Syndrome	Autosomal Recessive Spinocerebellar Ataxia Type 20
Intellectual Disability-Coarse Face-Macrocephaly-Cerebellar Hypoplasia Syndrome	Spinocerebellar Ataxia, Autosomal Recessive, 20
Ataxia, Spinocerebellar, Autosomal Recessive, Type 20

Intellectual Developmental Disorder, Autosomal Dominant 38

Psychomotor Retardation, Epilepsy, And Language Disability Syndrome	MRD38
Prelds	Autosomal Dominant Non-Syndromic Intellectual Disability 38
Mental Retardation, Autosomal Dominant 38	Autosomal Dominant Intellectual Developmental Disorder 38
Autosomal Dominant Mental Retardation 38	Mental Retardation, Autosomal Dominant, Type 38

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13536	SNX25 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNX25	RGD	RGD:1310150
Macaca mulatta	SNX25	VGNC	VGNC:77757
Canis familiaris	SNX25	VGNC	VGNC:46633
Mus musculus	SNX25	MGD	MGI:2142610
Bos taurus	SNX25	VGNC	VGNC:35104
Felis catus	SNX25	VGNC	VGNC:65552

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