SLC12A8 - solute carrier family 12 member 8 Gene

Also Known as CCC9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84561

About SLC12A8

Cytogenetic location: 3q21.2 Genomic coordinates (GRCh38): 3:125,082,644-125,212,748 (from NCBI)

This gene has 16 transcripts (splice variants), 191 orthologues and 8 paralogues. Broad expression in thyroid (RPKM 11.6), gall bladder (RPKM 6.0) and 17 other tissues.

Summary

This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]

SLC12A8 Products (2)

mRNA Protein Name
NM_001195483.2 NP_001182412.2 solute carrier family 12 member 8
NM_024628.6 NP_078904.4 solute carrier family 12 member 8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC12A8 Protein Structure

AA_permease

AA_permease: Amino acid permease (44 - 411)

  • 0
  • 200
  • 400
  • 600
  • 714 a.a.
Protein Preferred Names Protein Names

solute carrier family 12 member 8

  • cation-chloride cotransporter 9

SLC12A8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC12A8 A0AV02 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
SLC12A8 A0AV02 PAX6 Homo sapiens P26367
Validated Y2H
32296183
Intra
SLC12A8 A0AV02 PAX6 Homo sapiens P26367
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Psoriasis
Psoriasis 6

  • PSORS6

  • Psoriasis Susceptibility 6

  • Psoriasis 6, Susceptibility To
Psoriasis 8

  • PSORS8

  • Psoriasis Susceptibility 8

  • Psoriasis 8, Susceptibility To
Psoriasis 9

  • PSORS9

  • Psoriasis 9, Susceptibility To

  • Psoriasis Susceptibility 9
Psoriasis 10

  • PSORS10

  • Psoriasis Susceptibility 10

  • Psoriasis 10, Susceptibility To
Psoriasis 7

  • PSORS7

  • Psoriasis 7, Susceptibility To

  • Psoriasis Susceptibility 7

  • Psoriasis

  • Psoriasis Vulgaris

  • Pv
Corneal Abscess
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13003 SLC12A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC12A8 VGNC VGNC:46225
Felis catus SLC12A8 VGNC VGNC:65194
Mus musculus SLC12A8 MGD MGI:2443672
Rattus norvegicus SLC12A8 RGD RGD:628730
Bos taurus SLC12A8 VGNC VGNC:34671
Macaca mulatta SLC12A8 VGNC VGNC:84080
Others SLC12A8 NCBI