RGS5 - regulator of G protein signaling 5 Gene

Also Known as MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8490

About RGS5

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:163,142,299-163,321,735 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in adrenal (RPKM 143.5), thyroid (RPKM 96.0) and 20 other tissues.

Summary

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

RGS5 Products (12)

mRNA Protein Name
NM_001195303.3 NP_001182232.1 regulator of G-protein signaling 5 isoform 2
NM_001254748.2 NP_001241677.1 regulator of G-protein signaling 5 isoform 2
NM_001254749.2 NP_001241678.1 regulator of G-protein signaling 5 isoform 3
NM_001414472.1 NP_001401401.1 regulator of G-protein signaling 5 isoform 5
NM_001414473.1 NP_001401402.1 regulator of G-protein signaling 5 isoform 5
NM_001414474.1 NP_001401403.1 regulator of G-protein signaling 5 isoform 5
NM_001414475.1 NP_001401404.1 regulator of G-protein signaling 5 isoform 5
NM_001414476.1 NP_001401405.1 regulator of G-protein signaling 5 isoform 4
NM_001414477.1 NP_001401406.1 regulator of G-protein signaling 5 isoform 2
NM_001414478.1 NP_001401407.1 regulator of G-protein signaling 5 isoform 2
NM_001414479.1 NP_001401408.1 regulator of G-protein signaling 5 isoform 2
NM_003617.4 NP_003608.1 regulator of G-protein signaling 5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS5 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (64 - 179)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 5

  • regulator of G-protein signalling 5

RGS5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
RGS5 O15539 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
RGS5 O15539 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
RGS5 O15539 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RGS5 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P74596 RGS5 Protein, Human (His) O15539 (M1-K181) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11923 RGS5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19376 Rgs5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25868 Rgs5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RGS5 MGD MGI:1098434
Canis familiaris RGS5 VGNC VGNC:53128
Rattus norvegicus RGS5 RGD RGD:3568
Macaca mulatta RGS5 VGNC VGNC:100056
Bos taurus RGS5 VGNC VGNC:55670
Others RGS5 NCBI