LIPF - lipase F, gastric type Gene

Homo sapiens

Also known as GL; HGL; HLAL

Gene ID: 8513 | Gene type: protein coding

About LIPF

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:88,664,442-88,678,814 (from NCBI)

This gene has 6 transcripts (splice variants), 154 orthologues and 5 paralogues. Restricted expression toward stomach (RPKM 9296.8).

Summary

This gene encodes gastric Lipase, an Enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

LIPF Products(4)

mRNA	Protein	Name
NM_001198828.2	NP_001185757.1	gastric triacylglycerol lipase isoform 3 precursor
NM_001198829.2	NP_001185758.1	gastric triacylglycerol lipase isoform 1 precursor
NM_001198830.2	NP_001185759.1	gastric triacylglycerol lipase isoform 4 precursor
NM_004190.4	NP_004181.1	gastric triacylglycerol lipase isoform 2 precursor

LIPF Protein Structure

Abhydro_lipase

Abhydrolase_1

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

gastric triacylglycerol lipase

gastric lipase

Recombinant LIPF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70262	Gastric lipase Protein, Human (HEK293, His)	AAI12273.1 (L20-K398)	≥95%
HY-P70262A	Gastric lipase Protein, Human (HEK293, C-His)	P07098 (L20-K398)	≥95%

Related Diseases

Diseases

Alias

Lysosomal Acid Lipase Deficiency

Wolman Disease	Cholesteryl Ester Storage Disease
Lal Deficiency	Lipa Deficiency
Cholesterol Ester Storage Disease	CESD
Cholesterol Ester Hydrolase Deficiency	Acid Lipase Deficiency
Acid Esterase Deficiency	Familial Xanthomatosis
Wolman Xanthomatosis	Wolman'S Disease
Wolman'S Or Triglyceride Storage Type Iii Disease	Xanthomatosis, Familial
Liposomal Acid Lipase Deficiency, Wolman Type	Familial Visceral Xanthomatosis
Primary Familial Xanthomatosis	Primary Familial Xanthomatosis With Adrenal Calcification
Acid Lipase Disease	WOD
Acid Cholesteryl Ester Hydrolase Deficiency, Type 2

Cholesterol Ester Storage Disease

Lysosomal And Lipase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07688	LIPF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LIPF	VGNC	VGNC:107298
Mus musculus	LIPF	MGD	MGI:1914967
Macaca mulatta	LIPF	VGNC	VGNC:74422
Canis familiaris	LIPF	VGNC	VGNC:42696
Rattus norvegicus	LIPF	RGD	RGD:708441
Felis catus	LIPF	VGNC	VGNC:68058
Others	LIPF	NCBI