LIPF - lipase F, gastric type Gene

Also Known as GL; HGL; HLAL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8513

About LIPF

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:88,664,442-88,678,814 (from NCBI)

This gene has 6 transcripts (splice variants), 154 orthologues and 5 paralogues. Restricted expression toward stomach (RPKM 9296.8).

Summary

This gene encodes gastric Lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

LIPF Products (4)

mRNA Protein Name
NM_001198828.2 NP_001185757.1 gastric triacylglycerol lipase isoform 3 precursor
NM_001198829.2 NP_001185758.1 gastric triacylglycerol lipase isoform 1 precursor
NM_001198830.2 NP_001185759.1 gastric triacylglycerol lipase isoform 4 precursor
NM_004190.4 NP_004181.1 gastric triacylglycerol lipase isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
2243091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIPF Protein Structure

Abhydro_lipase

Abhydro_lipase: Partial alpha/beta-hydrolase lipase region (35 - 96)

Abhydrolase_1

Abhydrolase_1: alpha/beta hydrolase fold (111 - 381)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

gastric triacylglycerol lipase

  • gastric lipase

LIPF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIPF P07098 LRSAM1 Homo sapiens Q6UWE0
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LIPF Proteins

Cat. No. Product Name Accession Purity
HY-P70262A Gastric lipase Protein, Human (HEK293, His) P07098-1 (L20-K398) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lysosomal Acid Lipase Deficiency

  • Wolman Disease

  • Cholesteryl Ester Storage Disease

  • Lal Deficiency

  • Lipa Deficiency

  • Cholesterol Ester Storage Disease

  • CESD

  • Cholesterol Ester Hydrolase Deficiency

  • Acid Lipase Deficiency

  • Acid Esterase Deficiency

  • Familial Xanthomatosis

  • Wolman Xanthomatosis

  • Wolman'S Disease

  • Wolman'S Or Triglyceride Storage Type Iii Disease

  • Xanthomatosis, Familial

  • Liposomal Acid Lipase Deficiency, Wolman Type

  • Familial Visceral Xanthomatosis

  • Primary Familial Xanthomatosis

  • Primary Familial Xanthomatosis With Adrenal Calcification

  • Acid Lipase Disease

  • WOD

  • Acid Cholesteryl Ester Hydrolase Deficiency, Type 2
Cholesterol Ester Storage Disease
Lysosomal And Lipase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07688 LIPF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20767 Lipf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27281 Lipf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LIPF VGNC VGNC:107298
Mus musculus LIPF MGD MGI:1914967
Macaca mulatta LIPF VGNC VGNC:74422
Canis familiaris LIPF VGNC VGNC:42696
Rattus norvegicus LIPF RGD RGD:708441
Felis catus LIPF VGNC VGNC:68058
Others LIPF NCBI