CPZ - carboxypeptidase Z Gene

Homo sapiens

Gene ID: 8532 | Gene type: protein coding

About CPZ

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,592,765-8,619,752 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues and 7 paralogues. Biased expression in ovary (RPKM 47.9), placenta (RPKM 26.8) and 8 other tissues.

Summary

This gene encodes a member of the metallocarboxypeptidase family. This Enzyme displays Carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CPZ Products(3)

mRNA	Protein	Name
NM_001014447.3	NP_001014447.2	carboxypeptidase Z isoform 1 precursor
NM_001014448.3	NP_001014448.2	carboxypeptidase Z isoform 3
NM_003652.4	NP_003643.3	carboxypeptidase Z isoform 2 precursor

CPZ Protein Structure

Peptidase_M14

CarboxypepD_reg

0
100
200
300
400
500
600
652 a.a.

Protein Preferred Names

Protein Names

carboxypeptidase Z

VEZT/CPZ fusion

Related Diseases

Diseases

Alias

Locked-In Syndrome

Locked In Syndrome	Cerebromedullospinal Disconnection
Locked-In State	Quadriplegia

Epithelial-Stromal Tgfbi Dystrophy

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Cataract 11, Multiple Types

Cataract, Posterior Polar, 4	Ctpp4
Cpp4	Cataract 11 Multiple Types
CTRCT11	Cataract 11, Syndromic, Autosomal Recessive
Cataract 11 With Microphthalmia And Neurodevelopmental Abnormalities	Posterior Polar Cataract 4
Posterior Polar Cataract, 4	Cataract Posterior Polar 4
Syndromic Cataract 11	Cataract, Type 11, Multiple Types

Schizoid Personality Disorder

Sexual Sadism

Sadism

Amusia

Receptive Amusia

Myasthenic Syndrome, Congenital, 1a, Slow-Channel

Congenital Myasthenic Syndrome 1a	Congenital Myasthenic Syndrome 2a
CMS1A	Cms Iia
Congenital Myasthenic Syndrome Type Iia	Cms2a
Myasthenic Syndrome, Congenital, Type Iia, Formerly	Cms2a, Formerly
Cms Iia, Formerly	Congenital Myasthenic Syndrome 1a, Slow-Channel
Congenital Myasthenic Syndrome 2a Slow-Channel	Congenital Myasthenic Syndrome Post-Synaptic Slow-Channel
Myasthenic Syndrome, Congenital, Slow-Channel	Sccms
Myasthenic Syndrome, Congenital, Type 1a, Slow-Channel	Myasthenic Syndrome, Congenital, Postsynaptic Slow-Channel
Myasthenic Syndromes, Congenital, Slow Channel

Paranoid Personality Disorder

Phonagnosia

Myasthenic Syndrome, Congenital, 16

Congenital Myasthenic Syndrome 16	CMS16
Myasthenic Syndrome, Congenital, Acetazolamide-Responsive	Congenital Myasthenic Syndrome Acetazolamide-Responsive
Congenital Myasthenic Syndrome Due To Mutation In Scn4a	Congenital Myasthenic Syndrome Scn4a-Related

Bestiality

Zoophilia

Alexithymia

Schizotypal Personality Disorder

Schizotypal Personality

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Corneal Disease

Corneal Diseases

Corneal Disorders

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03130	CPZ Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CPZ	RGD	RGD:620496
Canis familiaris	CPZ	VGNC	VGNC:39587
Mus musculus	CPZ	MGD	MGI:88487
Macaca mulatta	CPZ	VGNC	VGNC:71478
Felis catus	CPZ	VGNC	VGNC:61153
Bos taurus	CPZ	VGNC	VGNC:27683