CPZ - carboxypeptidase Z Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8532

About CPZ

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,592,765-8,619,752 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues and 7 paralogues. Biased expression in ovary (RPKM 47.9), placenta (RPKM 26.8) and 8 other tissues.

Summary

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays Carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

CPZ Products (3)

mRNA Protein Name
NM_001014447.3 NP_001014447.2 carboxypeptidase Z isoform 1 precursor
NM_001014448.3 NP_001014448.2 carboxypeptidase Z isoform 3
NM_003652.4 NP_003643.3 carboxypeptidase Z isoform 2 precursor

CPZ Protein Structure

Fz

Fz: Fz domain (43 - 157)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (194 - 493)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (506 - 570)

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  • 652 a.a.
Protein Preferred Names Protein Names

carboxypeptidase Z

  • VEZT/CPZ fusion

Related Diseases

Diseases Alias
Locked-In Syndrome

  • Locked In Syndrome

  • Cerebromedullospinal Disconnection

  • Locked-In State

  • Quadriplegia
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

  • Familial Amyloid Neuropathy, Finnish Type

  • Familial Amyloid Polyneuropathy, Type V
Cataract 11, Multiple Types

  • Cataract, Posterior Polar, 4

  • Ctpp4

  • Cpp4

  • Cataract 11 Multiple Types

  • CTRCT11

  • Cataract 11, Syndromic, Autosomal Recessive

  • Cataract 11 With Microphthalmia And Neurodevelopmental Abnormalities

  • Posterior Polar Cataract 4

  • Posterior Polar Cataract, 4

  • Cataract Posterior Polar 4

  • Syndromic Cataract 11

  • Cataract, Type 11, Multiple Types
Schizoid Personality Disorder
Sexual Sadism

  • Sadism
Amusia

  • Receptive Amusia
Myasthenic Syndrome, Congenital, 1a, Slow-Channel

  • Congenital Myasthenic Syndrome 1a

  • Congenital Myasthenic Syndrome 2a

  • CMS1A

  • Cms Iia

  • Congenital Myasthenic Syndrome Type Iia

  • Cms2a

  • Myasthenic Syndrome, Congenital, Type Iia, Formerly

  • Cms2a, Formerly

  • Cms Iia, Formerly

  • Congenital Myasthenic Syndrome 1a, Slow-Channel

  • Congenital Myasthenic Syndrome 2a Slow-Channel

  • Congenital Myasthenic Syndrome Post-Synaptic Slow-Channel

  • Myasthenic Syndrome, Congenital, Slow-Channel

  • Sccms

  • Myasthenic Syndrome, Congenital, Type 1a, Slow-Channel

  • Myasthenic Syndrome, Congenital, Postsynaptic Slow-Channel

  • Myasthenic Syndromes, Congenital, Slow Channel
Paranoid Personality Disorder
Phonagnosia
Myasthenic Syndrome, Congenital, 16

  • Congenital Myasthenic Syndrome 16

  • CMS16

  • Myasthenic Syndrome, Congenital, Acetazolamide-Responsive

  • Congenital Myasthenic Syndrome Acetazolamide-Responsive

  • Congenital Myasthenic Syndrome Due To Mutation In Scn4a

  • Congenital Myasthenic Syndrome Scn4a-Related
Bestiality

  • Zoophilia
Alexithymia
Schizotypal Personality Disorder

  • Schizotypal Personality
Reading Disorder

  • Specific Reading Disorder

  • Reading

  • Dyslexia

  • Developmental Reading Disorder
Corneal Disease

  • Corneal Diseases

  • Corneal Disorders
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03130 CPZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12823 Caprazene / Unkown
HY-RS16701 Cpz Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23135 Cpz Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CPZ RGD RGD:620496
Canis familiaris CPZ VGNC VGNC:39587
Mus musculus CPZ MGD MGI:88487
Macaca mulatta CPZ VGNC VGNC:71478
Felis catus CPZ VGNC VGNC:61153
Bos taurus CPZ VGNC VGNC:27683
Others CPZ NCBI