ZIC5 - Zic family member 5 Gene

Homo sapiens

Gene ID: 85416 | Gene type: protein coding

About ZIC5

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,962,964-99,971,909 (from NCBI)

This gene has 1 transcript (splice variant), 237 orthologues and 14 paralogues. Restricted expression toward testis (RPKM 2.7).

Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to Cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]

ZIC5 Products(1)

mRNA	Protein	Name
NM_033132.5	NP_149123.3	zinc finger protein ZIC 5

ZIC5 Protein Structure

zf-H2C2_2

zf-C2H2

0
200
400
600
663 a.a.

Protein Preferred Names

Protein Names

zinc finger protein ZIC 5

Zic family member 5 (odd-paired homolog, Drosophila)

Related Diseases

Diseases

Alias

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Deafness, Autosomal Recessive 109

DFNB109	Autosomal Recessive Nonsyndromic Deafness 109
Autosomal Recessive Deafness 109	Deafness, Autosomal Recessive, 109

Dystonia 16

DYT16	Dyt-Prkra
Dystonia-16	Young-Onset Dystonia-
Early-Onset Dystonia Parkinsonism	Dystonia, Type 16

Brittle Cornea Syndrome 1

Brittle Cornea Syndrome	Fragilitas Oculi With Joint Hyperextensibility
Dysgenesis Mesodermalis Corneae Et Sclerae	BCS1
Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility	Ehlers-Danlos Syndrome, Type Vib, Formerly
Eds6b, Formerly	Type Vib Ehlers-Danlos Syndrome
Eds Vib	Ehlers-Danlos Syndrome Type 6b
Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility	Eds6b Formerly
Ehlers-Danlos Syndrome Type Vib Formerly	Ehlers-Danlos Syndrome Type 6
Cornea, Brittle, Syndrome	Cornea, Brittle, Syndrome, Type 1
Ehlers-Danlos Syndrome 6b

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16077	ZIC5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZIC5	VGNC	VGNC:106314
Felis catus	ZIC5	VGNC	VGNC:102369
Mus musculus	ZIC5	MGD	MGI:1929518
Bos taurus	ZIC5	VGNC	VGNC:107039
Canis familiaris	ZIC5	VGNC	VGNC:48635
Rattus norvegicus	ZIC5	RGD	RGD:1310160