ZIC5 - Zic family member 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 85416

About ZIC5

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,962,964-99,971,909 (from NCBI)

This gene has 1 transcript (splice variant), 237 orthologues and 14 paralogues. Restricted expression toward testis (RPKM 2.7).

Summary

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to Cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017]

ZIC5 Products (1)

mRNA	Protein	Name
NM_033132.5	NP_149123.3	zinc finger protein ZIC 5

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZIC5 Protein Structure

zf-H2C2_2

zf-C2H2

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
zinc finger protein ZIC 5	Zic family member 5 (odd-paired homolog, Drosophila)

Related Diseases

Diseases	Alias
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Deafness, Autosomal Recessive 109	DFNB109 Autosomal Recessive Nonsyndromic Deafness 109 Autosomal Recessive Deafness 109 Deafness, Autosomal Recessive, 109
Dystonia 16	DYT16 Dyt-Prkra Dystonia-16 Young-Onset Dystonia- Early-Onset Dystonia Parkinsonism Dystonia, Type 16
Brittle Cornea Syndrome 1	Brittle Cornea Syndrome Fragilitas Oculi With Joint Hyperextensibility Dysgenesis Mesodermalis Corneae Et Sclerae BCS1 Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility Ehlers-Danlos Syndrome, Type Vib, Formerly Eds6b, Formerly Type Vib Ehlers-Danlos Syndrome Eds Vib Ehlers-Danlos Syndrome Type 6b Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility Eds6b Formerly Ehlers-Danlos Syndrome Type Vib Formerly Ehlers-Danlos Syndrome Type 6 Cornea, Brittle, Syndrome Cornea, Brittle, Syndrome, Type 1 Ehlers-Danlos Syndrome 6b
Gapo Syndrome	GAPOS Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16077	ZIC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21463	Zic5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27981	Zic5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZIC5	VGNC	VGNC:106314
Felis catus	ZIC5	VGNC	VGNC:102369
Mus musculus	ZIC5	MGD	MGI:1929518
Bos taurus	ZIC5	VGNC	VGNC:107039
Canis familiaris	ZIC5	VGNC	VGNC:48635
Rattus norvegicus	ZIC5	RGD	RGD:1310160
Others	ZIC5	NCBI