Nbn - nibrin Gene

Also Known as Nbs1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85482

Summary

Predicted to enable DNA-binding transcription factor binding activity; damaged DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of neuron differentiation; negative regulation of viral entry into host cell; and regulation of fibroblast proliferation. Predicted to be located in chromosome and nucleus. Predicted to be part of Mre11 complex. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; breast cancer; and reproductive organ Cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Apr 2022]

Nbn Products (1)

mRNA Protein Name
NM_138873.2 NP_620228.1 nibrin

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
17442057 RGD
involved in negative regulation of viral entry into host cell IMP
IMP: Inferred from mutant phenotype
22850678 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17442057 RGD
involved in regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
12637527 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18253720 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nibrin

  • nijmegen breakage syndrome protein 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09057 NBN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01048 ARTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18740 Nbn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25227 Nbn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nbn NCBI NCBI:4683