IL18R1 - interleukin 18 receptor 1 Gene

Also Known as CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8809

About IL18R1

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,355,796-102,398,776 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 10 paralogues. Broad expression in appendix (RPKM 4.6), gall bladder (RPKM 3.7) and 21 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four Other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

IL18R1 Products (9)

mRNA	Protein	Name
NM_001282399.2	NP_001269328.1	interleukin-18 receptor 1 isoform 2
NM_001371418.1	NP_001358347.1	interleukin-18 receptor 1 isoform 3 precursor
NM_001371419.1	NP_001358348.1	interleukin-18 receptor 1 isoform 4 precursor
NM_001371420.1	NP_001358349.1	interleukin-18 receptor 1 isoform 5 precursor
NM_001371421.1	NP_001358350.1	interleukin-18 receptor 1 isoform 6
NM_001371422.1	NP_001358351.1	interleukin-18 receptor 1 isoform 7
NM_001371423.1	NP_001358352.1	interleukin-18 receptor 1 isoform 8
NM_001371424.1	NP_001358353.1	interleukin-18 receptor 1 isoform 8
NM_003855.5	NP_003846.1	interleukin-18 receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-18 binding	IDA IDA: Inferred from direct assay	14528293	GOA
enables interleukin-18 receptor activity	IDA IDA: Inferred from direct assay	25500532	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25261253	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	25500532	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	25500532	GOA
involved in positive regulation of T-helper 1 cell cytokine production	IDA IDA: Inferred from direct assay	10653850	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	10653850	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of interleukin-18 receptor complex	IDA IDA: Inferred from direct assay	25500532	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL18R1 Protein Structure

Ig_2

Ig_3

TIR

0
100
200
300
400
500
541 a.a.

Protein Preferred Names	Protein Names
interleukin-18 receptor 1	CD218 antigen-like family member A

IL18R1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL18R1	Q13478	IL18	Homo sapiens	Q14116	GMS	25261253

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL18R1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75842	IL-18R alpha Protein, Human (HEK293, Fc)	Q13478 (A19-R329)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75843	IL-18R alpha Protein, Human (HEK293, His)	Q13478 (A19-R329)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77710	IL-18R alpha Protein, Human (HEK293, His-Avi)	Q13478 (A19-R329)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77711	IL-18R alpha Protein, Human (Biotinylated, HEK293, His-Avi)	Q13478 (A19-R329)	≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Laron Syndrome	Growth Hormone Insensitivity Syndrome Growth Hormone Receptor Deficiency Laron Dwarfism Pituitary Dwarfism Ii Laron-Type Isolated Somatotropin Defect Primary Growth Hormone Resistance Laron-Type Dwarfism Laron Type Pituitary Dwarfism I Primary Growth Hormone Insensitivity Primary Gh Resistance Gh-R Deficiency Growth Hormone Receptor Defect Laron-Type Pituitary Dwarfism Laron-Type Short Stature Severe Gh Insensitivity Ghis Short Stature Due To A Defect In Growth Hormone Receptor Or Post-Receptor Pathway Complete Growth Hormone Insensitivity Gh Receptor Deficiency Primary Gh Insensitivity Short Stature Due To Growth Hormone Resistance LARS
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Childhood T-Cell Acute Lymphoblastic Leukemia	T-Cell Childhood Acute Lymphoblastic Leukemia Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia T-Cell Childhood Acute Lymphocytic Leukemia Childhood T Lymphoblastic Leukemia/Lymphoma
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Childhood-Onset Asthma	Childhood Asthma Asthma Childhood
Psoriasis
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06710	IL18R1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174630	Human IL18R1 mRNA		/	Unkown
HY-RS19262	Il18r1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25751	Il18r1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IL18R1	VGNC	VGNC:30127
Macaca mulatta	IL18R1	VGNC	VGNC:73714
Rattus norvegicus	IL18R1	RGD	RGD:1308589
Felis catus	IL18R1	VGNC	VGNC:67764
Canis familiaris	IL18R1	VGNC	VGNC:41953
Mus musculus	IL18R1	MGD	MGI:105383
Others	IL18R1	NCBI