FGD3 - FYVE, RhoGEF and PH domain containing 3 Gene

Also Known as ZFYVE5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 89846

About FGD3

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,947,523-93,036,233 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues and 10 paralogues. Broad expression in spleen (RPKM 16.0), lymph node (RPKM 14.2) and 17 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FGD3 Products (5)

mRNA Protein Name
NM_001083536.2 NP_001077005.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform a
NM_001286993.2 NP_001273922.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform b
NM_001369951.1 NP_001356880.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform a
NM_001369952.1 NP_001356881.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform c
NM_033086.3 NP_149077.2 FYVE, RhoGEF and PH domain-containing protein 3 isoform a

FGD3 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (161 - 339)

PH

PH: PH domain (371 - 468)

FYVE

FYVE: FYVE zinc finger (530 - 584)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
Protein Preferred Names Protein Names

FYVE, RhoGEF and PH domain-containing protein 3

  • FGD1 family, member 3

Related Diseases

Diseases Alias
Aarskog-Scott Syndrome

  • Aarskog Syndrome

  • Faciogenital Dysplasia

  • Faciodigitogenital Syndrome

  • AAS

  • Fgdy

  • X-Linked Aarskog Syndrome

  • Intellectual Developmental Disorder, X-Linked, Syndromic 16

  • Aarskog Syndrome, X-Linked

  • Intellectual Developmental Disorder, X-Linked Syndromic 16

  • Greig'S Syndrome

  • Aarskog Scott Syndrome

  • Aarskog Disease

  • Scott Aarskog Syndrome

  • Facio-Digito-Genital Dysplasia

  • Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

  • Aarskog-Scott Syndrome ) Syndrome
Familial Glucocorticoid Deficiency

  • Glucocorticoid Deficiency

  • Acth Resistance

  • Adrenal Unresponsiveness To Acth

  • Hereditary Unresponsiveness To Adrenocorticotropic Hormone

  • Isolated Glucocorticoid Deficiency

  • Glucocorticoid Deficiency, Familial

  • Glucocorticoid Deficiency 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04882 FGD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FGD3 VGNC VGNC:62241
Macaca mulatta FGD3 VGNC VGNC:72512
Rattus norvegicus FGD3 RGD RGD:1311725
Bos taurus FGD3 VGNC VGNC:28966
Canis familiaris FGD3 VGNC VGNC:40835
Mus musculus FGD3 MGD MGI:1353657
Others FGD3 NCBI