FGD3 - FYVE, RhoGEF and PH domain containing 3 Gene

Homo sapiens

Also known as ZFYVE5

Gene ID: 89846 | Gene type: protein coding

About FGD3

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,947,523-93,036,233 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues and 10 paralogues. Broad expression in spleen (RPKM 16.0), lymph node (RPKM 14.2) and 17 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FGD3 Products(5)

mRNA	Protein	Name
NM_001083536.2	NP_001077005.1	FYVE, RhoGEF and PH domain-containing protein 3 isoform a
NM_001286993.2	NP_001273922.1	FYVE, RhoGEF and PH domain-containing protein 3 isoform b
NM_001369951.1	NP_001356880.1	FYVE, RhoGEF and PH domain-containing protein 3 isoform a
NM_001369952.1	NP_001356881.1	FYVE, RhoGEF and PH domain-containing protein 3 isoform c
NM_033086.3	NP_149077.2	FYVE, RhoGEF and PH domain-containing protein 3 isoform a

FGD3 Protein Structure

RhoGEF

FYVE

0
200
400
600
725 a.a.

Protein Preferred Names

Protein Names

FYVE, RhoGEF and PH domain-containing protein 3

FGD1 family, member 3

Related Diseases

Diseases

Alias

Aarskog-Scott Syndrome

Aarskog Syndrome	Faciogenital Dysplasia
Faciodigitogenital Syndrome	AAS
Fgdy	X-Linked Aarskog Syndrome
Intellectual Developmental Disorder, X-Linked, Syndromic 16	Aarskog Syndrome, X-Linked
Intellectual Developmental Disorder, X-Linked Syndromic 16	Greig'S Syndrome
Aarskog Scott Syndrome	Aarskog Disease
Scott Aarskog Syndrome	Facio-Digito-Genital Dysplasia
Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder	Aarskog-Scott Syndrome ) Syndrome

Familial Glucocorticoid Deficiency

Glucocorticoid Deficiency	Acth Resistance
Adrenal Unresponsiveness To Acth	Hereditary Unresponsiveness To Adrenocorticotropic Hormone
Isolated Glucocorticoid Deficiency	Glucocorticoid Deficiency, Familial
Glucocorticoid Deficiency 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04882	FGD3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FGD3	VGNC	VGNC:62241
Macaca mulatta	FGD3	VGNC	VGNC:72512
Rattus norvegicus	FGD3	RGD	RGD:1311725
Bos taurus	FGD3	VGNC	VGNC:28966
Canis familiaris	FGD3	VGNC	VGNC:40835
Mus musculus	FGD3	MGD	MGI:1353657