FCMR - Fc mu receptor Gene

Also Known as TOSO; FAIM3; FcmuR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9214

About FCMR

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,903,317-206,921,941 (from NCBI)

This gene has 10 transcripts (splice variants), 92 orthologues and 13 paralogues. Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues.

Summary

Fc Receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

FCMR Products (18)

mRNA Protein Name
NM_001142473.2 NP_001135945.1 fas apoptotic inhibitory molecule 3 isoform b
NM_001193338.2 NP_001180267.1 fas apoptotic inhibitory molecule 3 isoform c precursor
NM_001405862.1 NP_001392791.1 fas apoptotic inhibitory molecule 3 isoform d
NM_001405863.1 NP_001392792.1 fas apoptotic inhibitory molecule 3 isoform d
NM_001405864.1 NP_001392793.1 fas apoptotic inhibitory molecule 3 isoform e precursor
NM_001405865.1 NP_001392794.1 fas apoptotic inhibitory molecule 3 isoform e precursor
NM_001405866.1 NP_001392795.1 fas apoptotic inhibitory molecule 3 isoform f precursor
NM_001405867.1 NP_001392796.1 fas apoptotic inhibitory molecule 3 isoform g precursor
NM_001405868.1 NP_001392797.1 fas apoptotic inhibitory molecule 3 isoform g precursor
NM_001405871.1 NP_001392800.1 fas apoptotic inhibitory molecule 3 isoform a precursor
NM_001405886.1 NP_001392815.1 fas apoptotic inhibitory molecule 3 isoform h
NM_001405887.1 NP_001392816.1 fas apoptotic inhibitory molecule 3 isoform b
NM_001405888.1 NP_001392817.1 fas apoptotic inhibitory molecule 3 isoform j
NM_001405889.1 NP_001392818.1 fas apoptotic inhibitory molecule 3 isoform k precursor
NM_001405890.1 NP_001392819.1 fas apoptotic inhibitory molecule 3 isoform l
NM_001405891.1 NP_001392820.1 fas apoptotic inhibitory molecule 3 isoform m
NM_001405892.1 NP_001392821.1 fas apoptotic inhibitory molecule 3 isoform n precursor
NM_005449.5 NP_005440.1 fas apoptotic inhibitory molecule 3 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables high-affinity IgM receptor activity IDA
IDA: Inferred from direct assay
19858324 GOA
enables polymeric immunoglobulin binding IDA
IDA: Inferred from direct assay
36949194 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
36949194 GOA
Biological Process GO Annotation Evidence References Source
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: Inferred from direct assay
21908732 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
21908732 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
21908732 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19858324 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
21908732 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCMR Protein Structure

ig

ig: Immunoglobulin domain (30 - 105)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

fas apoptotic inhibitory molecule 3

  • Fc fragment of IgM receptor

Recombinant FCMR Proteins

Cat. No. Product Name Accession Purity
HY-P77364 FCMR/FAIM3 Protein, Human (HEK293, Fc) O60667-1/NP_005440.1 (R18-G251) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Immunodeficiency 54

  • Natural Killer Cell Deficiency, Familial Isolated

  • Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency

  • IMD54

  • Nkcd

  • Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect

  • Nkgcd

  • Familial Isolated Natural Killer Cell Deficiency

  • Primary Immunodeficiency Due To Mcm4 Deficiency
Pinguecula
Conjunctival Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04838 FCMR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18931 Fcmr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25421 Fcmr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FCMR VGNC VGNC:72507
Rattus norvegicus FCMR RGD RGD:1359282
Canis familiaris FCMR VGNC VGNC:40808
Felis catus FCMR VGNC VGNC:62214
Bos taurus FCMR VGNC VGNC:28938
Mus musculus FCMR MGD MGI:1916419
Others FCMR NCBI