AIMP1 - aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Gene

Also Known as p43; HLD3; EMAP2; SCYE1; EMAPII

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9255

About AIMP1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:106,315,544-106,349,456 (from NCBI)

This gene has 19 transcripts (splice variants), 306 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.6), prostate (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is a cytokine that is specifically induced by Apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

AIMP1 Products (3)

mRNA Protein Name
NM_001142415.2 NP_001135887.1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor
NM_001142416.2 NP_001135888.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor
NM_004757.4 NP_004748.2 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11741979 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11306575 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
11306575 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell signaling IDA
IDA: Inferred from direct assay
11741979 GOA
involved in leukocyte migration IDA
IDA: Inferred from direct assay
11306575 GOA
involved in negative regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
11741979 GOA
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
10791971 GOA
located in cell surface IDA
IDA: Inferred from direct assay
11741979 GOA
located in cytosol IDA
IDA: Inferred from direct assay
19289464 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AIMP1 Protein Structure

tRNA_bind

tRNA_bind: Putative tRNA binding domain (157 - 249)

  • 0
  • 100
  • 200
  • 312 a.a.
Protein Preferred Names Protein Names

aminoacyl tRNA synthase complex-interacting multifunctional protein 1

  • ARS-interacting multifunctional protein 1

AIMP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AIMP1 Q12904 TSNAX Homo sapiens Q99598
Validated Y2H
25416956
Intra
AIMP1 Q12904 AIMP2 Homo sapiens Q13155
Anti Tag CoIP
33961781
Intra
AIMP1 Q12904 AIMP2 Homo sapiens Q13155
Anti Tag CoIP
28514442
Intra
AIMP1 Q12904 AIMP2 Homo sapiens Q13155
Y2H Array
25416956
Cross
AIMP1 Q12904 P04591-PRO_0000038593 Human immunodeficiency virus P04591-PRO_0000038593
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

AIMP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83018 EMAP II Antibody (YA2763) WB Human, Mouse, Rat
HY-P83018A EMAP II Antibody (YA2763)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Leukodystrophy, Hypomyelinating, 3

  • Hypomyelinating Leukodystrophy 3

  • HLD3

  • Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation

  • Leukodystrophy, Hypomyelinating 3

  • Perinatal Sudanophilic Leukodystrophy

  • Leukodystrophy, Hypomyelinating, Type 3

  • Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2
Autosomal Recessive Non-Syndromic Intellectual Disability

  • Ar-Nsid

  • Ns-Arid
Hypotonia
Hypomyelinating Leukodystrophy

  • Hld

  • Leukodystrophy, Hypomyelinating
Fibrosarcoma

  • Neoplasms, Fibrous Tissue

  • Fibrocytic Tumor

  • Fibrosarcoma Of Soft Tissue

  • Fibrous Tissue Neoplasm
Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

  • HLD7

  • Leukoencephalopathy-Ataxia-Hypodontia-Hypomyelination Syndrome

  • Addh

  • Leukodystrophy, Hypomyelinating, With Hypodontia And Hypogonadotropic Hypogonadism

  • 4h Syndrome

  • 4h Leukodystrophy 1

  • Hypomyelinating Leukodystrophy 7 With Or Without Oligodontia And-Or Hypogonadotropic Hypogonadism

  • Hypomyelination-Cerebellar Atrophy-Hypoplasia Of The Corpus Callosum Syndrome

  • Leukodystrophy With Oligodontia

  • Tach Syndrome

  • Tremor-Ataxia-Central Hypomyelination Syndrome

  • Leukoencephalopathy, Hypomyelinating, With Ataxia And Delayed Dentition

  • Ataxia, Delayed Dentition, And Hypomyelination

  • Ataxia-Delayed Dentition-Hypomyelination Syndrome

  • Odontoleukodystrophy

  • Dentoleukoencephalopathy

  • Hypomyelinating Leukodystrophy-Ataxia-Hypodontia-Hypomyelination Syndrome

  • Ataxia-Delayed Dentition-Hypomyelination Syndrome

  • Ataxia Delayed Dentition And Hypomyelination

  • Leukodystrophy Hypomyelinating With Hypodontia And Hypogonadotropic Hypogonadism 4h Syndrome

  • Leukoencephalopathy Hypomyelinating With Ataxia And Delayed Dentition

  • Tach

  • Tremor-Ataxia With Central Hypomyelination

  • Attention Deficit Hyperactivity Disorder

  • Leukodystrophy, Dysmyelinating, With Oligodontia
Leukodystrophy, Hypomyelinating, 9

  • Hypomyelinating Leukodystrophy 9

  • HLD9

  • Rars-Related Autosomal Recessive Hypomyelinating Leukodystrophy

  • Leukodystrophy, Hypomyelinating, Type 9
Leukodystrophy

  • Leukodystrophies
Charcot-Marie-Tooth Disease, Dominant Intermediate C

  • CMTDIC

  • Charcot-Marie-Tooth Disease Dominant Intermediate C

  • Di-Cmtc

  • Autosomal Dominant Intermediate Charcot-Marie-Tooth Disease Type C

  • Charcot-Marie-Tooth Neuropathy, Dominant Intermediate C

  • Charcot-Marie-Tooth Neuropathy Dominant Intermediate C

  • Charcot-Marie-Tooth Disease, Dominant, Intermediate Type, C

  • Charcot-Marie-Tooth Disease, Dominant Intermediate, Type C
Pelizaeus-Merzbacher Disease

  • PMD

  • HLD1

  • Pelizaeus-Merzbacher Brain Sclerosis

  • Leukodystrophy, Hypomyelinating, 1

  • Diffuse Familial Brain Sclerosis

  • Pelizaeus Merzbacher Brain Sclerosis

  • Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type

  • Cockayne-Pelizaeus-Merzbacher Disease

  • Hypomyelinating Leukodystrophy 1

  • Leukodystrophy, Sudanophilic

  • Pelizaeus Merzbacher Disease

  • Hypomyelinating Leukodystrophy, 1

  • Sudanophilic Leukodystrophy

  • Pelizaeus-Merzbacher Disease, Connatal Form

  • Connatal Pmd

  • Pelizaeus-Merzbacher Disease Type Ii

  • Severe Pmd

  • Null Syndrome

  • Plp1 Null Syndrome

  • Pelizaeus-Merzbacher Disease, Null Syndrome

  • Brain Sclerosis Diffuse Familial

  • Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type

  • Leukodystrophy Hypomyelinating 1

  • Diffuse Cerebral Sclerosis Of Schilder
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00497 AIMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18159 Aimp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24633 Aimp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus AIMP1 VGNC VGNC:25765
Rattus norvegicus AIMP1 RGD RGD:620466
Felis catus AIMP1 VGNC VGNC:78451
Canis familiaris AIMP1 VGNC VGNC:103659
Macaca mulatta AIMP1 VGNC VGNC:69599
Mus musculus AIMP1 MGD MGI:102774
Others AIMP1 NCBI