SELENOF - selenoprotein F Gene

Also Known as SEP15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9403

About SELENOF

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:86,862,445-86,914,577 (from NCBI)

This gene has 7 transcripts (splice variants), 136 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 119.6), urinary bladder (RPKM 69.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in Cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016]

SELENOF Products (2)

mRNA Protein Name
NM_004261.5 NP_004252.2 selenoprotein F isoform 1 precursor
NM_203341.3 NP_976086.1 selenoprotein F isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29410696 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
11278576 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOF Protein Structure

Sep15_SelM

Sep15_SelM: Sep15/SelM redox domain (85 - 160)

  • 0
  • 100
  • 162 a.a.
Protein Preferred Names Protein Names

selenoprotein F

  • 15 kDa selenoprotein

SELENOF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SELENOF O60613 RDH11 Homo sapiens Q8TC12
Y2H
29410696
Intra
SELENOF O60613 RDH11 Homo sapiens Q8TC12
FRET
29410696
Intra
SELENOF O60613 RDH11 Homo sapiens Q8TC12
Pull Down
29410696
Intra
SELENOF O60613 RDH11 Homo sapiens Q8TC12
Anti Tag CoIP
29410696
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Keshan Disease

  • Caused By Deficiency Of Selenium In The Diet

  • Enlarged Heart And Poor Heart Function
Rigid Spine Muscular Dystrophy 1

  • Rigid Spine Syndrome

  • RSMD1

  • Rss

  • Mdrs1

  • Eichsfeld Type Congenital Muscular Dystrophy

  • Desmin-Related Myopathy With Mallory Bodies

  • Classic Multiminicore Myopathy

  • Sepn1-Related Myopathy

  • Multicore Myopathy, Severe Classic Form

  • Minicore Myopathy, Severe Classic Form

  • Multiminicore Disease, Severe Classic Form

  • Muscular Dystrophy, Rigid Spine, 1

  • Classic Mmd

  • Classic Multiminicore Disease

  • Congenital Merosin-Positive Muscular Dystrophy With Early Spine Rigidity

  • Desmin-Related Myopathy With Mallory Body-Like Inclusions

  • Early-Onset Desmin-Related Myopathy

  • Myopathy, Sepn1-Related

  • Muscular Dystrophy, Congenital, Merosin-Positive, With Early Spine Rigidity

  • Muscular Dystrophy, Congenital, Eichsfeld Type

  • Severe Classic Form Minicore Myopathy

  • Severe Classic Form Multicore Myopathy

  • Severe Classic Form Multiminicore Disease

  • Desmin-Related Myopathies With Mallory Bodies

  • Muscular Dystrophy, Congenital, Merosin Positive With Early Spine Rigidity

  • Rigid Spine Muscular Dystrophy-1

  • Rigid Spine Congenital Muscular Dystrophy

  • Congenital Muscular Dystrophy Eichsfeld Type

  • Congenital Muscular Dystrophy Merosin-Positive With Early Spine Rigidity

  • Minicore Myopathy Severe Classic Form

  • Multicore Myopathy Severe Classic Form

  • Multiminicore Disease Severe Classic Form

  • Dystrophy, Muscular, Rigid Spine, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12634 SELENOF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SELENOF VGNC VGNC:80354
Bos taurus SELENOF VGNC VGNC:109402
Mus musculus SELENOF MGD MGI:1927947
Rattus norvegicus SELENOF RGD RGD:621291
Others SELENOF NCBI