2. Gene
  3. SPAG6 - sperm associated antigen 6 Gene

SPAG6 - sperm associated antigen 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as pf16; CT141; FAP194; CFAP194; Repro-SA-1

Gene ID: 9576 | Gene type: protein coding

About SPAG6

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:22,345,496-22,417,610 (from NCBI)

This gene has 9 transcripts (splice variants) and 225 orthologues. Restricted expression toward testis (RPKM 51.7).

Summary

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm Antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

SPAG6 Products(4)

mRNA Protein Name
NM_001253854.2 NP_001240783.1 sperm-associated antigen 6 isoform 3
NM_001253855.2 NP_001240784.1 sperm-associated antigen 6 isoform 4
NM_012443.4 NP_036575.1 sperm-associated antigen 6 isoform 1
NM_172242.3 NP_758442.1 sperm-associated antigen 6 isoform 2

SPAG6 Protein Structure

Arm

Arm: Armadillo/beta-catenin-like repeat (114 - 154)

Arm

Arm: Armadillo/beta-catenin-like repeat (157 - 195)

Arm

Arm: Armadillo/beta-catenin-like repeat (198 - 236)

Arm

Arm: Armadillo/beta-catenin-like repeat (327 - 363)

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  • 509 a.a.
Protein Preferred Names Protein Names

sperm-associated antigen 6

axoneme central apparatus protein

Related Diseases

Diseases Alias
Infertility
Tympanosclerosis

Ts - [Tympanosclerosis]

Tympanic Membrane Sclerosis
Tympanic Membrane Disease

Disorder Of Tympanic Membrane
Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos
Otitis Media

Opsoclonus-Myoclonus Syndrome

OMS

Otitis Media, Susceptibility To

Kinsbourne Syndrome

Otitis Media, Chronic/Recurrent

Come/Rom

Ataxo-Opso-Myoclonus Syndrome

Dancing Eye Syndrome

Dancing Eye-Dancing Feet Syndrome

Oma Syndrome

Opsoclonus Myoclonus Syndrome

Opsoclonus-Myoclonus-Ataxia Syndrome

Poma Syndrome

Paraneoplastic Opsoclonus-Myoclonus

Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome

Opsoclonus Myoclonus

OM

{Otitis Media, Susceptibility To}

Infectious Otitis Media
Cataract 4, Multiple Types

Cataract 4 Multiple Types

CTRCT4

Cca3

Pcc

Aculeiform Cataract

Cataract 4, Multiple Types, With Or Without Microcornea

Cataract, Crystalline Aculeiform

Caca

Cataract, Congenital, Cerulean Type, 3

Congenital Cataract Cerulean Type 3

Cataract Congenital Dominant Non Nuclear

Ccp

Cataract, Nonnuclear Polymorphic Congenital

Cataract, Punctate, Progressive Juvenile-Onset

Cataract 4 Multiple Types With Or Without Microcornea

Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract

Cataract, Polymorphic Congenital

Congenital Cataract Blue Dot Type 3

Congenital Non-Nuclear Polymorphic Cataract

Crystalline Aculeiform Cataract

Punctate, Progressive Juvenile-Onset, Cataract

Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Cerebral Degeneration

Brain Degeneration

Degenerative Brain Disorder
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13625 SPAG6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SPAG6 VGNC VGNC:35167
Canis familiaris SPAG6 VGNC VGNC:46696
Macaca mulatta SPAG6 VGNC VGNC:77851
Rattus norvegicus SPAG6 RGD RGD:1305616
Mus musculus SPAG6 MGD MGI:3040687
Felis catus SPAG6 VGNC VGNC:65597