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SPAG6 - sperm associated antigen 6 Gene

Also Known as pf16; CT141; FAP194; CFAP194; Repro-SA-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9576

About SPAG6

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:22,345,496-22,417,610 (from NCBI)

This gene has 9 transcripts (splice variants) and 225 orthologues. Restricted expression toward testis (RPKM 51.7).

Summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

SPAG6 Products (4)

mRNA	Protein	Name
NM_001253854.2	NP_001240783.1	sperm-associated antigen 6 isoform 3
NM_001253855.2	NP_001240784.1	sperm-associated antigen 6 isoform 4
NM_012443.4	NP_036575.1	sperm-associated antigen 6 isoform 1
NM_172242.3	NP_758442.1	sperm-associated antigen 6 isoform 2

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in axoneme	IDA IDA: Inferred from direct assay	10493827	GOA
located in sperm principal piece	IDA IDA: Inferred from direct assay	30137358	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPAG6 Protein Structure

Arm

0
100
200
300
400
509 a.a.

Protein Preferred Names	Protein Names
sperm-associated antigen 6	axoneme central apparatus protein

Related Diseases

Diseases	Alias
Infertility
Tympanosclerosis	Ts - [Tympanosclerosis] Tympanic Membrane Sclerosis
Tympanic Membrane Disease	Disorder Of Tympanic Membrane
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Cataract 4, Multiple Types	Cataract 4 Multiple Types CTRCT4 Cca3 Pcc Aculeiform Cataract Cataract 4, Multiple Types, With Or Without Microcornea Cataract, Crystalline Aculeiform Caca Cataract, Congenital, Cerulean Type, 3 Congenital Cataract Cerulean Type 3 Cataract Congenital Dominant Non Nuclear Ccp Cataract, Nonnuclear Polymorphic Congenital Cataract, Punctate, Progressive Juvenile-Onset Cataract 4 Multiple Types With Or Without Microcornea Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract Cataract, Polymorphic Congenital Congenital Cataract Blue Dot Type 3 Congenital Non-Nuclear Polymorphic Cataract Crystalline Aculeiform Cataract Punctate, Progressive Juvenile-Onset, Cataract Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Cerebral Degeneration	Brain Degeneration Degenerative Brain Disorder
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13625	SPAG6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22818	Spag6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SPAG6	VGNC	VGNC:35167
Canis familiaris	SPAG6	VGNC	VGNC:46696
Macaca mulatta	SPAG6	VGNC	VGNC:77851
Rattus norvegicus	SPAG6	RGD	RGD:1305616
Mus musculus	SPAG6	MGD	MGI:3040687
Felis catus	SPAG6	VGNC	VGNC:65597
Others	SPAG6	NCBI