GDA - guanine deaminase Gene

Also Known as GAH; CYPIN; GUANASE; NEDASIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9615

About GDA

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:72,114,608-72,259,869 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Biased expression in small intestine (RPKM 33.5), duodenum (RPKM 32.2) and 6 other tissues.

Summary

This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GDA Products (7)

mRNA Protein Name
NM_001242505.3 NP_001229434.1 guanine deaminase isoform a
NM_001242506.3 NP_001229435.1 guanine deaminase isoform c
NM_001242507.3 NP_001229436.1 guanine deaminase isoform c
NM_001351571.2 NP_001338500.1 guanine deaminase isoform d
NM_001351572.2 NP_001338501.1 guanine deaminase isoform a
NM_001351573.2 NP_001338502.1 guanine deaminase isoform e
NM_004293.5 NP_004284.1 guanine deaminase isoform b

GDA Protein Structure

Amidohydro_1

Amidohydro_1: Amidohydrolase family (75 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
Protein Preferred Names Protein Names

guanine deaminase

  • cytoplasmic PSD-95 interactor

GDA Antibodies

Cat. No. Product Name Application Reactivity
HY-P81391 GDA Antibody (YA1136) IHC-P Human
HY-P81391A GDA Antibody (YA1136)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Keratosis, Seborrheic

  • Seborrheic Keratosis

  • Keratosis, Seborrheic, Somatic

  • Basal Cell Papilloma

  • Keratosis Seborrheica

  • KERSEB
Acanthoma
Purine-Pyrimidine Metabolic Disorder

  • Inborn Errors Of Purine-Pyrimidine Metabolism

  • Disorder Of Purine Or Pyrimidine Metabolism
Hyperuricemia, Hprt-Related

  • Hprt-Related Gout

  • Kelley-Seegmiller Syndrome

  • Hprt Deficiency, Partial

  • HRH

  • Gout, Hprt-Related

  • Hprt1 Deficiency, Partial

  • Hrpt-Related Hyperuricemia

  • Hprt Deficiency, Grade I

  • Hprt Partial Deficiency

  • Hprt-Related Hyperuricemia

  • Hprt1 Partial Deficiency

  • Hypoxanthine Guanine Phosphoribosyltransferase 1 Partial Deficiency

  • Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade I

  • Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency

  • Partial Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

  • Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency, Partial

  • Hyperuricemia, Hrpt-Related
Lesch-Nyhan Syndrome

  • Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

  • LNS

  • Hprt Deficiency

  • Complete Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

  • Hypoxanthine Guanine Phosphoribosyltransferase Deficiency

  • X-Linked Hyperuricemia

  • Choreoathetosis Self-Mutilation Syndrome

  • Hprt1 Deficiency

  • Hprt Deficiency, Complete

  • Deficiency Of Imp Pyrophosphorylase

  • Hgprt Deficiency

  • Lesch-Nyhan Disease

  • Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency

  • Hg-Prt Deficiency

  • Hypoxanthine-Guanine-Phosphoribosyltransferase Deficiency

  • Lesch - Nyhan Syndrome

  • Hprt1 Disorders

  • Lesch Nyhan Syndrome

  • Complete Hprt Deficiency Complete

  • Lesch Nyhan Disease

  • Complete Hprt Deficiency

  • Deficiency Of Guanine Phosphoribosyltransferase

  • Deficiency Of Hypoxanthine Phosphoribosyltransferase

  • Hypoxanthine Phosphoribosyltransferase Deficiency

  • Juvenile Gout, Choreoathetosis, Mental Retardation Syndrome

  • Juvenile Hyperuricemia Syndrome

  • Lnd

  • Primary Hyperuricemia Syndrome

  • Total Hprt Deficiency

  • Total Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency

  • X-Linked Primary Hyperuricemia

  • X-Linked Uric Aciduria Enzyme Defect

  • Hprt Complete Deficiency

  • Hprt Deficiency Grade Iv

  • Hypoxanthine Guanine Phosphoribosyltransferase Complete Deficiency

  • Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade Iv

  • Hypoxanthine-Guanine Phosphoribosyltransferase 1 Deficiency

  • Hprt - [ Hypoxanthine-Guanine Phosphoribosyltransferase] Complete Deficiency

  • Total Hgprt - [Hypoxanthine-Guanine Phosphoribosyltransferase] Deficiency
Xanthinuria

  • Xanthine Dehydrogenase Deficiency

  • Xanthine Oxidase Deficiency

  • Hereditary Xanthinuria

  • Xanthic Urolithiasis

  • Xanthine Stone Disease

  • Xanthinuria, Type I

  • Combined Deficiency Of Xanthine Dehydrogenase And Aldehyde Oxidase

  • Xdh Deficiency

  • Classic Xanthinuria

  • Xanthinuria, Type Ii

  • Classical Xanthinuria

  • Xanthine Calculus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09965 PAEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145269 AL-GDa62 Inhibitor / Unkown
HY-RS05345 GDA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13096 SLC25A16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18216 Gda Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24693 Gda Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GDA RGD RGD:621617
Felis catus GDA VGNC VGNC:62497
Mus musculus GDA MGD MGI:95678
Macaca mulatta GDA VGNC VGNC:72906
Canis familiaris GDA VGNC VGNC:41154
Bos taurus GDA VGNC VGNC:29294
Others GDA NCBI