LPIN2 - lipin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9663

About LPIN2

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:2,916,994-3,013,144 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 28.7), duodenum (RPKM 22.4) and 25 other tissues.

Summary

Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and Insulin resistance. [provided by RefSeq, Jul 2008]

LPIN2 Products (3)

mRNA Protein Name
NM_001375808.2 NP_001362737.1 phosphatidate phosphatase LPIN2
NM_001375809.1 NP_001362738.1 phosphatidate phosphatase LPIN2
NM_014646.2 NP_055461.1 phosphatidate phosphatase LPIN2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphatidate phosphatase activity EXP
EXP: Inferred from Experiment
18694939 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPIN2 Protein Structure

Lipin_N

Lipin_N: lipin, N-terminal conserved region (1 - 113)

LNS2

LNS2: LNS2 (Lipin/Ned1/Smp2) (685 - 841)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 896 a.a.
Protein Preferred Names Protein Names

phosphatidate phosphatase LPIN2

LPIN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89607 Lipin-2 Antibody (YA8951) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Majeed Syndrome

  • MJDS

  • Chronic Recurrent Multifocal Osteomyelitis, Congenital Dyserythropoietic Anemia, And Neutrophilic Dermatosis

  • Cda And Crmo

  • Chronic Recurrent Multifocal Osteomyelitis, Congenital

  • Congenital Dyserythropoietic Anemia And Chronic Recurrent Multifocal Osteomyelitis

  • Dyserythropoietic Anemia, And Neutrophilic Dermatosis

  • Chronic Recurrent Multifocal Osteomyelitis-Congenital Dyserythropoietic Anemia-Neutrophilic Dermatosis Syndrome

  • Chronic Recurrent Multifocal Osteomyelitis With Congenital Dyserythropoietic Anemia And Neutrophilic Dermatosis
Chronic Recurrent Multifocal Osteomyelitis

  • Chronic Multifocal Osteomyelitis

  • CRMO

  • Cmo

  • Cno/Crmo

  • Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis

  • Osteomyelitis, Chronic Multifocal

  • Multifocal Osteomyelitis, Chronic

  • Chronic Osteomyelitis

  • Chronic Multifocal Osteomyelitis, Unspecified Site

  • Crmo - [Chronic Multifocal Osteomyelitis]

  • Chronic Osteomyelitis With Draining Sinus, Unspecified Site

  • Bone Fistula With Chronic Osteomyelitis
Osteomyelitis
Autoinflammatory Syndrome
Hypochromic Microcytic Anemia

  • Anemia, Hypochromic Microcytic

  • Microcytic Hypochromic Anemia
Sapho Syndrome

  • Acquired Hyperostosis Syndrome

  • Synovitis, Acne, Pustulosis Palmaris, Hyperostosis, Osteomyelitis Syndrome

  • Synovitis Acne Pustulosis Hyperostosis Osteitis

  • Synovitis, Acne, Pustlosis, Hyperostosis, And Osteomyelitis

  • Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis Syndrome

  • Synovitis, Acne, Pustulosis, Hyperostosis, And Osteitis Syndrome

  • Pustulo-Psoriatic Hyperostotic Spondylarthritis

  • Sapho - [Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis] Syndrome
Congenital Dyserythropoietic Anemia

  • Congenital Dyshaematopoietic Anaemia

  • Dyserythropoietic Anemia, Congenital

  • Cda

  • Anemia, Dyserythropoietic, Congenital

  • Anemia Dyserythropoietic Congenital

  • Cda - [Congenital Dyserythropoietic Anaemia]

  • Dyserythropoietic Dyshaematopoietic Congenital Anaemia

  • Dyshaematopoietic Anaemia

  • Dyserythropoietic Anaemia
Microcytic Anemia

  • Iron-Refractory Iron Deficiency Anemia
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

  • Papa Syndrome

  • Fra

  • Familial Recurrent Arthritis

  • Pyogenic Arthritis, Pyoderma Gangrenosum And Acne

  • PAPAS

  • Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome

  • Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne

  • Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne
Miliaria Pustulosa
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Neutrophilic Dermatosis, Acute Febrile

  • Sweet Syndrome

  • Acute Febrile Neutrophilic Dermatosis

  • Ss

  • AFND

  • Pyrin-Associated Autoinflammatory Disease

  • PAAND

  • Gomm-Button Disease

  • Sweet'S Syndrome

  • Gomm Button Disease

  • Sweets Syndrome

  • Acromelic Frontonasal Dysostosis

  • Sweet Disease
Periostitis
Pustulosis Of Palm And Sole

  • Psoriasis

  • Acropustulosis

  • Palmoplantar Pustulosis

  • Pustular Psoriasis Of The Palms And/Or Soles

  • Pustulosis Of Palms And Soles

  • Acrodermatitis Continua Of Hallopeau

  • Generalized Pustular Psoriasis
Pityriasis Rubra Pilaris

  • PRP

  • Devergie'S Disease

  • Prp - [Pityriasis Rubra Pilaris]
Polyposis Syndrome, Hereditary Mixed, 2

  • HMPS2

  • Hereditary Mixed Polyposis Syndrome 2

  • Polyposis Syndrome, Mixed Hereditary 2

  • Polyposis Syndrome, Hereditary Mixed, Type 2
Pyoderma Gangrenosum

  • Phagedenic Pyoderma

  • Phagedena Geometric
Mevalonic Aciduria

  • Mevalonate Kinase Deficiency

  • Mevalonicaciduria

  • Hyperimmunoglobulin D With Periodic Fever

  • MEVA

  • Complete Mevalonate Kinase Deficiency

  • Mva

  • Hyperimmunoglobulinemia D

  • Hyper Igd Syndrome

  • Periodic Fever, Dutch Type

  • Mkd

  • Aciduria, Mevalonic

  • Deficiency Of Mevalonate Kinase
Sebaceous Gland Disease

  • Sebaceous Gland Anomaly

  • Sebaceous Gland Diseases
Pyoderma
Porokeratosis

  • Disseminated Superficial Actinic Porokeratosis

  • Dsap

  • Porokeratosis Of Mibelli

  • Porokeratosis, Disseminated Superficial Actinic

  • Porokeratosis, Disseminated Superficial Actinic, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07770 LPIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22613 Lpin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29128 Lpin2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LPIN2 VGNC VGNC:63269
Mus musculus LPIN2 MGD MGI:1891341
Bos taurus LPIN2 VGNC VGNC:30967
Rattus norvegicus LPIN2 RGD RGD:1304588
Macaca mulatta LPIN2 VGNC VGNC:74288
Canis familiaris LPIN2 VGNC VGNC:42752
Others LPIN2 NCBI