PRORP - protein only RNase P catalytic subunit Gene

Also Known as MRPP3; COXPD54; KIAA0391

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9692

About PRORP

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,121,839-35,277,622 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 10.2), kidney (RPKM 8.4) and 25 other tissues.

Summary

Enables ribonuclease P activity. Involved in mitochondrial tRNA 5'-end processing. Located in mitochondrion and nucleoplasm. Part of mitochondrial ribonuclease P complex. [provided by Alliance of Genome Resources, Apr 2022]

PRORP Products (6)

mRNA Protein Name
NM_001256678.2 NP_001243607.1 mitochondrial ribonuclease P catalytic subunit isoform 2
NM_001256679.2 NP_001243608.1 mitochondrial ribonuclease P catalytic subunit isoform 3
NM_001256680.2 NP_001243609.1 mitochondrial ribonuclease P catalytic subunit isoform 4
NM_001256681.2 NP_001243610.1 mitochondrial ribonuclease P catalytic subunit isoform 4
NM_001414503.1 NP_001401432.1 mitochondrial ribonuclease P catalytic subunit isoform 1 precursor
NM_014672.4 NP_055487.2 mitochondrial ribonuclease P catalytic subunit isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ribonuclease P activity IDA
IDA: Inferred from direct assay
25953853 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in mitochondrial tRNA 5'-end processing IDA
IDA: Inferred from direct assay
25953853 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of mitochondrial ribonuclease P complex IDA
IDA: Inferred from direct assay
25953853 GOA
part of mitochondrial ribonuclease P complex IPI
IPI: Inferred from physical interaction
29880640 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
29880640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial ribonuclease P catalytic subunit

  • mitochondrial RNase P protein 3

Related Diseases

Diseases Alias
Combined Oxidative Phosphorylation Deficiency 54

  • COXPD54
Perrault Syndrome 1

  • PRLTS1

  • Ovarian Dysgenesis With Sensorineural Deafness

  • Gonadal Dysgenesis Xx Type Deafness

  • Gonadal Dysgenesis, Xx Type, With Deafness

  • Gonadal Dysgenesis Xx Type With Deafness
Hypertonia
Lactic Acidosis

  • Acidosis, Lactic

  • Acidosis Lactic
Syndromic X-Linked Intellectual Disability Type 10

  • Hsd10 Deficiency, Atypical Type

  • Hsd10 Disease, Atypical Type

  • X-Linked Intellectual Disability-Choreoathetosis-Abnormal Behavior Syndrome

  • Mrxs10

  • Mental Retardation, X-Linked, Syndromic 10
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Anterior Spinal Artery Syndrome

  • Anterior Spinal Artery Occlusion Syndrome
Codas Syndrome

  • Cerebral, Ocular, Dental, Auricular, And Skeletal Anomalies Syndrome

  • Cerebral, Ocular, Dental, Auricular, And Skeletal Syndrome

  • Cerebro-Oculo-Dento-Auriculo-Skeletal Syndrome

  • Cerebrooculodentoauriculoskeletal Syndrome

  • CODASS

  • Cerebral, Ocular, Dental, Auricular, Skeletal Syndrome
Perrault Syndrome

  • Gonadal Dysgenesis, Xx Type, With Deafness

  • Ovarian Dysgenesis With Sensorineural Deafness

  • Gonadal Dysgenesis, Xx Type

  • Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance

  • Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance

  • Xx Gonodal Dysgenesis-Deafness Syndrome

  • Xx Gonodal Dysgenesis-Hearing Loss Syndrome

  • Gonadal Dysgenesis Xx Type Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11201 PRORP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22742 Prorp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29256 Prorp Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PRORP VGNC VGNC:84425
Rattus norvegicus PRORP RGD RGD:1305089
Felis catus PRORP VGNC VGNC:80885
Bos taurus PRORP VGNC VGNC:55893
Mus musculus PRORP MGD MGI:1913382
Others PRORP NCBI