KDM2B-IN-4
Based on 1 Customer Validation
KDM2B-IN-4 (Compound 182b) is a histone demethylase KDM2B inhibitor with an IC50 of 1.12 nM. KDM2B-IN-4 can be used for the research of hyperproliferative diseases such as cancers.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 1966933-85-6
- Formula: C24H28N2O2
- Molecular Weight:376.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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KDM2 |
Chemical Information
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CAS No. 1966933-85-6
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Appearance Solid
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Molecular Weight 376.49
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Formula C24H28N2O2
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Color Off-white to light yellow
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SMILES
N#CCC1=C(OC)C=CC2=C1C=CC(C([C@@H]3CN(C4CCC4)CC[C@@H]3C)=O)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (265.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6561 mL | 13.2806 mL | 26.5611 mL | 66.4028 mL |
| 5 mM | 0.5312 mL | 2.6561 mL | 5.3122 mL | 13.2806 mL | |
| 10 mM | 0.2656 mL | 1.3281 mL | 2.6561 mL | 6.6403 mL | |
| 15 mM | 0.1771 mL | 0.8854 mL | 1.7707 mL | 4.4269 mL | |
| 20 mM | 0.1328 mL | 0.6640 mL | 1.3281 mL | 3.3201 mL | |
| 25 mM | 0.1062 mL | 0.5312 mL | 1.0624 mL | 2.6561 mL | |
| 30 mM | 0.0885 mL | 0.4427 mL | 0.8854 mL | 2.2134 mL | |
| 40 mM | 0.0664 mL | 0.3320 mL | 0.6640 mL | 1.6601 mL | |
| 50 mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.3281 mL | |
| 60 mM | 0.0443 mL | 0.2213 mL | 0.4427 mL | 1.1067 mL | |
| 80 mM | 0.0332 mL | 0.1660 mL | 0.3320 mL | 0.8300 mL | |
| 100 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.6640 mL |
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