A Critical Review on Advancement in Analytical Strategies for the Quantification of Clinically Relevant Biological Transporters

  • Crit Rev Anal Chem. 2022;52(7):1557-1571. doi: 10.1080/10408347.2021.1891859.
Mustafa Modiwala  1 ,  Tarang Jadav  1 ,  Amit Kumar Sahu  1 ,  Rakesh K Tekade  1 ,  Pinaki Sengupta  1
Affiliations
  • 1. National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Gandhinagar, Gujarat, India.
PMID: 33691566 DOI: 10.1080/10408347.2021.1891859
Abstract

Success of a drug discovery program is highly dependent on rapid scientific advancement and periodic inclusion of sensitive and specific analytical techniques. Biological membrane transporters can significantly alter the bioavailability of a molecule in its actual site of action. Expression of transporter proteins responsible for drug transport is extremely low in the biological system. Therefore, proper scientific planning in selection of their quantitative analytical technique is essential. This article discusses critical advancement in the analytical strategies for quantification of clinically relevant biological transporters for the drugs. Article cross-talked key planning and execution strategies concerning analytical quantification of the transporters during drug discovery programs.

Keywords
Analytical techniques; biological transporters; drug discovery; execution strategies; quantitation.
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