MLNR - motilin receptor Gene

Also Known as GPR38; MTLR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2862

About MLNR

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,220,338-49,222,377 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a Motilin Receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]

MLNR Products (1)

mRNA Protein Name
NM_001507.1 NP_001498.1 motilin receptor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IPI
IPI: Inferred from physical interaction
10381885 GOA
enables hormone binding IPI
IPI: Inferred from physical interaction
10381885 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLNR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (55 - 182)

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (233 - 355)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
Protein Preferred Names Protein Names

motilin receptor

  • G protein-coupled receptor 38

Related Diseases

Diseases Alias
Superior Mesenteric Artery Syndrome

  • Wilkie Syndrome

  • Wilkie'S Syndrome

  • Arteriomesenteric Duodenal Compression Syndrome

  • Cast Syndrome

  • Vascular Compression Of The Duodenum

  • Smas

  • Arteriomesenteric Compression Of Duodenojejunal Flexure
Intestinal Pseudo-Obstruction

  • Chronic Intestinal Pseudoobstruction

  • Chronic Intestinal Pseudo-Obstruction

  • Cipo

  • Neuronal Intestinal Dysplasia

  • Hollow Visceral Myopathy

  • Familial Visceral Neuropathy

  • Paralytic Ileus

  • Intestinal Pseudoobstruction

  • Chronic Idiopathic Intestinal Pseudo-Obstruction

  • Ciip

  • Congenital Short Bowel Syndrome

  • Enteric Neuropathy

  • Familial Visceral Myopathy

  • Ipo

  • Pseudo-Obstruction Of Intestine

  • Pseudointestinal Obstruction Syndrome

  • Pseudoobstructive Syndrome

  • Congenital Idiopathic Intestinal Pseudoobstruction

  • Visceral Myopathy, Familial
Constipation
Diabetic Autonomic Neuropathy

  • Diabetic Neuropathies
Pylorospasm
Gastroparesis

  • Gastroparesis Syndrome

  • Delayed Gastric Emptying

  • Gastric Atonia

  • Gastroparalysis
Benign Essential Hypertension
Hypertrophic Pyloric Stenosis

  • Congenital Hypertrophic Pyloric Stenosis

  • Pyloric Stenosis, Hypertrophic

  • Congenital Or Infantile Stricture Of Pylorus

  • Achalasia Of The Pylorus

  • Congenital Hypertrophy Of The Pylorus

  • Infantile Hypertrophy Of The Pylorus

  • Infantile Constriction Of The Pylorus

  • Congenital Stenosis Of The Pylorus

  • Congenital Constriction Of The Pylorus

  • Congenital Stricture Of The Pylorus

  • Infantile Hypertrophic Pyloric Stenosis

  • Infantile Stenosis Of The Pylorus

  • Infantile Stricture Of The Pylorus

  • Congenital Or Infantile Constriction Of Pylorus

  • Infantile Pyloric Obstruction

  • Infantile Pyloric Hypertrophy

  • Pylorus Achalasia

  • Pyloric Constriction

  • Infantile Pyloric Stricture

  • Infantile Pyloric Stenosis

  • Congenital Spasm Of Pylorus

  • Congenital Pylorospasm

  • Congenital Pyloric Stricture

  • Congenital Pyloric Spasm

  • Congenital Or Infantile Spasm Of Pylorus

  • Congenital Or Infantile Obstruction Of Pylorus

  • Congenital Pyloric Stenosis
Functional Colonic Disease

  • Colonic Diseases, Functional
Functional Gastric Disease
Rumination Disorder

  • Rumination Syndrome

  • Psychogenic Rumination

  • Rumination Disorders
Lung Occult Small Cell Carcinoma

  • Occult Small Cell Carcinoma Of Lung

  • Occult Small Cell Carcinoma Of The Lung
Gallbladder Disease

  • Gallbladder Diseases

  • Gall Bladder

  • Gall Bladder Diseases

  • Abnormal Gallbladder Function
Colonic Pseudo-Obstruction

  • Primary Chronic Pseudo-Obstruction Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08499 MLNR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08500 Mlnr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown