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Cat. No.: HY-15882

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GNE-783

GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines.

For research use only. We do not sell to patients.

CAS No.: 1200127-66-7
Formula: C₂₂H₂₀N₆
Molecular Weight:368.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

GNE-783 Chemical Structure

CAS No.: 1200127-66-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	EC₅₀	97.7 nM Compound: 1, GNE-783	Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assay Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assay	[PMID: 25988399]
HT-29	GI₅₀	>25 μM Compound: 16, GNE-783	Antiproliferative activity against human HT-29 cells assessed as growth inhibition Antiproliferative activity against human HT-29 cells assessed as growth inhibition	[PMID: 25453805]
HT-29	IC₅₀	0.098 μM Compound: 16, GNE-783	Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assay Inhibition of ChK1 in human HT-29 cells assessed as phospho-histone H3 by Isobologram assay	[PMID: 25453805]

Chemical Information

CAS No. 1200127-66-7
Molecular Weight 368.43
Formula C₂₂H₂₀N₆
SMILES

N#CC1=NC=C2C(C3=CC(C4=CC=C(N5CCN(C)CC5)C=C4)=CN=C3N2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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