1200127-66-7
Chemical Structure
GNE-783
- CAS No.: 1200127-66-7
- Formula:C22H20N6
- Molecular Weight:368.43
IUPAC Name: 3-(4-(4-methylpiperazin-1-yl)phenyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile
InChIKey: PVRJSOWSQUNARV-UHFFFAOYSA-N
SMILES: N#CC1=NC=C2C(C3=CC(C4=CC=C(N5CCN(C)CC5)C=C4)=CN=C3N2)=C1
Biological Activity: GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines[1].
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GNE-783 | GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines. | |||||||||||||||||||||
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Keywords
