Olive oil
Based on 6 publication(s) in Google Scholar
Olive oil (Cropure OL) is an oleaginous compound found in the fruit of the Olea europaea tree. Olive oil contains many phenolic components and exerts antioxidant activity. Olive oil exhibits hydroxyl radical scavenging, platelet aggregation inhibition and xanthine oxidase inhibitory activity. Olive oil can promote wound healing and relieve inflammation. Olive oil can be used for the research of inflammation, cancer, metabolic and cardiovascular disease, such as diabetic foot ulcers and inflammatory bowel disease.
For research use only. We do not sell to patients.
- CAS No.: 8001-25-0
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Olive oil
More
Biological Activity
Olive oil exhibits hydroxyl radical scavenging and xanthine oxidase inhibitory activity, with 73% inhibition of xanthine oxidase activity[2].
Olive oil contains phenolic components (hydroxytyrosol and oleuropein) potently inhibit copper sulfate-induced oxidation of isolated LDL in vitro[3].
Olive oil contains phenolic components (hydroxytyrosol and oleuropein) exhibit non-antioxidant biological activities in vitro, including inhibition of human platelet aggregation and leukocyte eicosanoid production (hydroxytyrosol, with an EC50 in the 10−5 M range) and increased nitric oxide production by lipopolysaccharide-treated murine macrophages (oleuropein)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar[4]
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Dosage:Aqueous solution containing olive oil and HT
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Administration:intrarectal
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Result:Reduced the severity of inflammatory damage in the TNBS-induced colitis model, with reduced inflammatory infiltrate.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 8001-25-0
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Appearance Liquid (Density: 0.9135 g/cm3)
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Color Colorless to light yellow
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SMILES
[Olive oil]
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Synonyms
Cropure OL
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Phytother Res
Geniposide modulates GSK3β to inhibit Th17 differentiation and mitigate endothelial damage in intracranial aneurysm. [Abstract]2024 Nov;38(11):5184-5202. PMID: 39180344 -
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Food Funct
Dual improvement effects of ω-3 on bone loss and liver injury in rats with liver-bone axis damage. [Abstract]2026 Apr 14;17(7):3229-3247. PMID: 41834729 -
J Inflamm Res
Gut Microbiota Mitigates Chronic Itch and Cutaneous Inflammation in DNFB-Induced Atopic Dermatitis Mice. [Abstract]2026 Feb 6:19:573709. PMID: 41890815 -
Chin J Integr Med
Total Flavonoids of Litchi chinensis Sonn. Seed Improves Hepatic Fibrosis by Inhibiting PANoptosis. [Abstract]2025 Dec 9. PMID: 41361707
Solvent & Solubility
DMSO : 100 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Malik S, et al. Olive Oil Shows Promise for Wound Healing of Ulcers. Cutis. 2024;113(6):260-263. [Content Brief]
[2]. Owen RW, et al. Olives and olive oil in cancer prevention. Eur J Cancer Prev. 2004 Aug;13(4):319-26. [Content Brief]
[3]. Visioli F, et al. Antiatherogenic components of olive oil. Curr Atheroscler Rep. 2001;3(1):64-67. [Content Brief]
[4]. Vrdoljak J, et al. Effects of Olive Oil and Its Components on Intestinal Inflammation and Inflammatory Bowel Disease. Nutrients. 2022;14(4):757. Published 2022 Feb 11. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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