PRSS21 - serine protease 21 Gene

Also Known as ESP1; ESP-1; TEST1; TESTISIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10942

About PRSS21

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,817,237-2,821,719 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 182 orthologues and 17 paralogues. Biased expression in testis (RPKM 26.0), bone marrow (RPKM 4.4) and 4 other tissues.

Summary

This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PRSS21 Products (4)

mRNA Protein Name
NM_001270452.2 NP_001257381.1 testisin isoform 4 preproprotein
NM_006799.4 NP_006790.1 testisin isoform 1 preproprotein
NM_144956.3 NP_659205.1 testisin isoform 2 preproprotein
NM_144957.3 NP_659206.1 testisin isoform 3 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211623 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS21 Protein Structure

Trypsin

Trypsin: Trypsin (42 - 281)

  • 0
  • 100
  • 200
  • 300
  • 314 a.a.
Protein Preferred Names Protein Names

testisin

  • eosinophil serine protease 1

PRSS21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRSS21 Q9Y6M0 SERPINB5 Homo sapiens P36952
Pull Down
20211623
Intra
PRSS21 Q9Y6M0 SERPINB5 Homo sapiens P36952
IF
20211623
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Inflammatory Bowel Disease 12

  • IBD12
Cataract 37

  • CTRCT37

  • Cca5

  • Cataract, Congenital, Cerulean Type, 5

  • Cataract 37, Autosomal Dominant

  • Congenital Cataract Cerulean Type 5
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11249 PRSS21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRSS21 RGD RGD:727870
Mus musculus PRSS21 MGD MGI:1916698
Macaca mulatta PRSS21 VGNC VGNC:76432
Others PRSS21 NCBI