NUDT6 - nudix hydrolase 6 Gene

Also Known as GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11162

About NUDT6

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:122,892,577-122,922,968 (from NCBI)

This gene has 8 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues.

Summary

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NUDT6 Products (2)

mRNA Protein Name
NM_007083.5 NP_009014.2 nucleoside diphosphate-linked moiety X motif 6 isoform a
NM_198041.3 NP_932158.1 nucleoside diphosphate-linked moiety X motif 6 isoform b

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
11266510 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11266510 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11266510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT6 Protein Structure

NUDIX

NUDIX: NUDIX domain (143 - 265)

  • 0
  • 100
  • 200
  • 300
  • 316 a.a.
Protein Preferred Names Protein Names

nucleoside diphosphate-linked moiety X motif 6

  • antisense basic fibroblast growth factor

Related Diseases

Diseases Alias
Desmoid Disease, Hereditary

  • Fif

  • DESMD

  • Hereditary Desmoid Disease

  • Familial Infiltrative Fibromatosis

  • Fibromatosis, Familial Infiltrative

  • Fibromatosis, Aggressive
Gingival Overgrowth

  • Gingival Enlargement

  • Gingival Hyperplasia

  • Gingival Bulge

  • Gingival Enlargement Nos

  • Gingival Hypertrophy

  • Gum Hypertrophy

  • Hyperplasia Gum

  • Gingival Thickening

  • Hyperplasia Of Gingiva

  • Hypertrophy Of Gingiva

  • Hypertrophy Of Mucous Membrane Of Gums
Central Neurocytoma

  • Neurocytoma

  • Neurolipocytoma

  • Neurocytoma Central
Gastric Ulcer

  • Stomach Ulcer

  • Acute Gastric Ulcer With Haemorrhage And Perforation

  • Acute Gastric Ulcer With Hemorrhage And Obstruction

  • Acute Gastric Ulcer With Hemorrhage And Perforation

  • Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

  • Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

  • Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

  • Acute Gastric Ulcer With Hemorrhage, With Obstruction

  • Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

  • Acute Gastric Ulcer With Perforation

  • Acute Gastric Ulcer With Perforation And Obstruction

  • Acute Gastric Ulcer With Perforation, With Obstruction

  • Acute Gastric Ulcer Without Hemorrhage And Without Perforation

  • Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

  • Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

  • Bleeding Acute Gastric Ulcer

  • Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

  • Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

  • Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

  • Gastric Ulcers

  • Cushings Ulcer

  • Cushing'S Ulcer Of Stomach

  • Peptic Ulcer Of Stomach

  • Mucosal Defect Of The Stomach
Glioma
Multiple Endocrine Neoplasia, Type I

  • Multiple Endocrine Neoplasia Type 1

  • MEN1

  • Wermer Syndrome

  • Multiple Endocrine Neoplasia 1

  • Multiple Endocrine Neoplasia, Type 1

  • Men I

  • Endocrine Adenomatosis, Multiple

  • Mea I

  • Men Type I

  • Wermer'S Syndrome

  • Men1 Syndrome

  • Multiple Endocrine Adenomatosis

  • Endocrine Adenomatosis Multiple

  • Men 1

  • Familial Multiple Endocrine Neoplasia Type I

  • Neoplasia, Endocrine, Multiple, Type 1

  • Multiple Endocrine Neoplasia
Cartilage Cancer

  • Chondrogenic Neoplasm
Retinal Degeneration

  • Degeneration Of Retina
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09674 NUDT6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUDT6 RGD RGD:621356
Bos taurus NUDT6 VGNC VGNC:32340
Felis catus NUDT6 VGNC VGNC:78540
Macaca mulatta NUDT6 VGNC VGNC:75553
Mus musculus NUDT6 MGD MGI:2387618
Canis familiaris NUDT6 VGNC VGNC:54811
Others NUDT6 NCBI