Ppp3ca - protein phosphatase 3, catalytic subunit, alpha isoform Gene

Also Known as CN; CnA; Caln; Calna; 2900074D19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19055

Summary

Enables Calmodulin binding activity and calmodulin-dependent protein Phosphatase activity. Involved in several processes, including negative regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of cardiac muscle hypertrophy in response to stress; and positive regulation of connective tissue replacement. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; cardiac muscle hypertrophy in response to stress; and regulation of transcription, DNA-templated. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of Calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; jaw; and thymus primordium. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein Phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3ca Products (2)

mRNA Protein Name
NM_001293622.1 NP_001280551.1 protein phosphatase 3 catalytic subunit alpha isoform 2
NM_008913.5 NP_032939.1 protein phosphatase 3 catalytic subunit alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
26794871 MGI
enables calmodulin-dependent protein phosphatase activity IDA
IDA: Inferred from direct assay
26794871 MGI
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
16024798 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12574411 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12660151 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
9017603 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IGI
IGI: Inferred from genetic interaction
18676376 MGI
acts upstream of or within calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
9515963 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
12660151 MGI
acts upstream of or within calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
19560418 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IGI
IGI: Inferred from genetic interaction
12370307 MGI
acts upstream of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23407945 MGI
acts upstream of or within dephosphorylation IDA
IDA: Inferred from direct assay
12574411 MGI
involved in epidermis development IMP
IMP: Inferred from mutant phenotype
19626032 MGI
acts upstream of or within excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
17428973 MGI
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
19626032 MGI
acts upstream of or within modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
15590926 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
10200317 MGI
acts upstream of or within multicellular organismal response to stress IDA
IDA: Inferred from direct assay
11782539 MGI
acts upstream of or within negative regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
23407945 MGI
acts upstream of or within negative regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
23407945 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
24161931 MGI
involved in negative regulation of signaling IMP
IMP: Inferred from mutant phenotype
26029823 MGI
acts upstream of or within positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
23261540 MGI
involved in positive regulation of activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
8627154 MGI
involved in positive regulation of cardiac muscle hypertrophy IGI
IGI: Inferred from genetic interaction
24161931 MGI
involved in positive regulation of cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
19287093 MGI
involved in positive regulation of connective tissue replacement IGI
IGI: Inferred from genetic interaction
24657879 MGI
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
20032460 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
24161931 MGI
involved in positive regulation of glomerulus development IMP
IMP: Inferred from mutant phenotype
15509543 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
16286645 MGI
involved in positive regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
16968888 MGI
involved in positive regulation of saliva secretion IMP
IMP: Inferred from mutant phenotype
21435446 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12808150 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17229811 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24161931 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
11257222 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11257222 MGI
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
26794871 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
19560418 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
11782539 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
31637311 MGI
involved in regulation of cell proliferation involved in kidney morphogenesis IMP
IMP: Inferred from mutant phenotype
15509543 MGI
involved in renal filtration IMP
IMP: Inferred from mutant phenotype
16735444 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
16024798 MGI
involved in skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
12773574 MGI
acts upstream of or within transition between fast and slow fiber IDA
IDA: Inferred from direct assay
21427212 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
11257222 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
11257222 MGI
located in Z disc IDA
IDA: Inferred from direct assay
15665106 MGI
part of calcineurin complex IDA
IDA: Inferred from direct assay
12617961 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16286645 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12617961 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11257222 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
11257222 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12617961 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12617961 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 3 catalytic subunit alpha

serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

  • CAM-PRP catalytic subunit

  • CNA alpha

  • PP2B alpha 1

  • PP2BA alpha

  • calcineurin A alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11023 PPP3CA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19521 Ppp3ca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26016 Ppp3ca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp3ca NCBI NCBI:5530