COPZ1 - COPI coat complex subunit zeta 1 Gene

Also Known as COPZ; CGI-120; HSPC181; zeta-COP; zeta1-COP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22818

About COPZ1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,325,131-54,351,846 (from NCBI)

This gene has 18 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 49.0), colon (RPKM 30.9) and 25 other tissues.

Summary

This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in Autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

COPZ1 Products (4)

mRNA Protein Name
NM_001271734.2 NP_001258663.1 coatomer subunit zeta-1 isoform 2
NM_001271735.2 NP_001258664.1 coatomer subunit zeta-1 isoform 3
NM_001271736.2 NP_001258665.1 coatomer subunit zeta-1 isoform 4
NM_016057.3 NP_057141.1 coatomer subunit zeta-1 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in intra-Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
11056392 GOA
Cellular Component GO Annotation Evidence References Source
part of COPI vesicle coat IDA
IDA: Inferred from direct assay
11056392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPZ1 Protein Structure

Clat_adaptor_s

Clat_adaptor_s: Clathrin adaptor complex small chain (12 - 151)

  • 0
  • 100
  • 177 a.a.
Protein Preferred Names Protein Names

coatomer subunit zeta-1

  • coatomer protein complex subunit zeta 1

Recombinant COPZ1 Proteins

Cat. No. Product Name Accession Purity
HY-P76847 COPZ1 Protein, Human/Mouse/Rat (His) P61923/NP_001101587.1 (M1-R177) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Menkes Disease

  • Copper Transport Disease

  • Menkes Syndrome

  • MNK

  • Kinky Hair Disease

  • Steely Hair Disease

  • Menkes Kinky-Hair Syndrome

  • Mk

  • Steely Hair Syndrome

  • Menkea Syndrome

  • Md

  • Menkes Kinky Hair Syndrome

  • Hypocupremia, Congenital

  • Kinky Hair Syndrome

  • X-Linked Copper Deficiency

  • Menkes Kinky Hair Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03034 COPZ1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20001 Copz1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26504 Copz1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus COPZ1 MGD MGI:1929063
Macaca mulatta COPZ1 VGNC VGNC:71318
Rattus norvegicus COPZ1 RGD RGD:1306154
Bos taurus COPZ1 VGNC VGNC:27607
Felis catus COPZ1 VGNC VGNC:83540
Others COPZ1 NCBI