Ppm1l - protein phosphatase 1 (formerly 2C)-like Gene

Also Known as PP2C; Pp2ce; Ppp2ce; mKIAA4175; 3222401G13; PP2Cepsilon; 5930404J21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 242083

Summary

Enables protein serine/threonine Phosphatase activity. Acts upstream of or within MAPK cascade and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including ganglia; gut; limb segment; metanephros; and sensory organ. Orthologous to human PPM1L (protein Phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Apr 2022]

Ppm1l Products (1)

mRNA Protein Name
NM_178726.3 NP_848841.2 protein phosphatase 1L

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12556533 MGI
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12556533 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IPI
IPI: Inferred from physical interaction
12823230 MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IDA
IDA: Inferred from direct assay
12823230 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1L

  • PP2C-epsilon

  • protein phosphatase 1-like

  • protein phosphatase 2C epsilon

Ppm1l Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Ppm1l Q8BHN0 ACBD3 Homo sapiens Q9H3P7
Pull Down
22796112
Cross
Ppm1l Q8BHN0 MARK3 Homo sapiens P27448
Phosphatase Assay
12556533
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10969 PPM1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppm1l NCBI NCBI:151742