PPM1L - protein phosphatase, Mg2+/Mn2+ dependent 1L Gene

Homo sapiens

Also known as PP2CE; PPM1-LIKE; PP2C-epsilon

Gene ID: 151742 | Gene type: protein coding

About PPM1L

Cytogenetic location: 3q25.33-q26.1 Genomic coordinates (GRCh38): 3:160,756,231-161,078,902 (from NCBI)

This gene has 5 transcripts (splice variants), 270 orthologues and 16 paralogues. Ubiquitous expression in brain (RPKM 9.7), thyroid (RPKM 6.9) and 24 other tissues.

Summary

The protein encoded by this gene is a magnesium or manganese-requiring Phosphatase that is involved in several signaling pathways. The encoded protein downregulates Apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to Apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PPM1L Products(3)

mRNA	Protein	Name
NM_001317911.2	NP_001304840.1	protein phosphatase 1L isoform 2
NM_001317912.2	NP_001304841.1	protein phosphatase 1L isoform 3
NM_139245.4	NP_640338.2	protein phosphatase 1L isoform 1

PPM1L Protein Structure

PP2C

0
100
200
300
360 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1L

PP2C epsilon

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 3

IBD3

Inflammatory Bowel Disease 6

IBD6

Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1	IBD1
Crohn Disease-Associated Growth Failure	Crohn Disease
Regional Enteritis	Ulcerative Colitis
Crohn Disease-Associated Growth Failure, Susceptibility To	Inflammatory Bowel Disease 1, Crohn Disease
Bowel Disease, Inflammatory, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10969	PPM1L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPM1L	RGD	RGD:1305220
Macaca mulatta	PPM1L	VGNC	VGNC:76265
Canis familiaris	PPM1L	VGNC	VGNC:44871
Felis catus	PPM1L	VGNC	VGNC:64314
Bos taurus	PPM1L	VGNC	VGNC:33216
Mus musculus	PPM1L	MGD	MGI:2139740

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