Map3k3 - mitogen-activated protein kinase kinase kinase 3 Gene

Also Known as Mekk3; MAPKKK3; mKIAA4031

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26406

Summary

Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; heart; and metanephros. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Map3k3 Products (1)

mRNA Protein Name
NM_011947.4 NP_036077.1 mitogen-activated protein kinase kinase kinase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12912994 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
10700190 MGI
acts upstream of or within positive regulation of p38MAPK cascade IDA
IDA: Inferred from direct assay
10700190 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 3

  • MAPK/ERK kinase kinase 3

  • MEK kinase 3

  • MEKK 3

Map3k3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Map3k3 Q61084 Map2k5 Mus musculus Q9WVS7
Pull Down
12912994
Intra
Map3k3 Q61084 Map2k5 Mus musculus Q9WVS7
CoIP
12912994
Intra
Map3k3 Q61084 Traf6 Mus musculus P70196
CoIP
14661019
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08056 MAP3K3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18870 Map3k3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25361 Map3k3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map3k3 NCBI NCBI:4215