Map2k5 - mitogen-activated protein kinase kinase 5 Gene

Also Known as MEK5; Mapkk5; Prkmk5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23938

About Map2k5

Chromosome 9: 63,071,050-63,285,184 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 209 orthologues, 8 paralogues and is associated with 11 phenotypes. Ubiquitous expression in adrenal adult (RPKM 1.5), thymus adult (RPKM 8.4) and 28 other tissues.

Summary

Predicted to enable ATP binding activity and MAP kinase kinase activity. Acts upstream of or within MAPK cascade and heart development. Located in spindle. Is expressed in early conceptus; oocyte; and telencephalon. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map2k5 Products (4)

mRNA Protein Name
NM_001364493.1 NP_001351422.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 3
NM_001364494.1 NP_001351423.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 4
NM_001364492.1 NP_001351421.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 2
NM_011840.3 NP_035970.1 dual specificity mitogen-activated protein kinase kinase 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
19654213 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12912994 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
15601854 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15601854 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
19654213 MGI
Cellular Component GO Annotation Evidence References Source
located in spindle IDA
IDA: Inferred from direct assay
15509711 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k5 Protein Structure

PB1_Map2k5

PB1_Map2k5: cd06395 (16 - 106)

PKc_MKK5

PKc_MKK5: cd06619 (163 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 448 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 5

  • MAP kinase kinase 5

  • MAPK/ERK kinase 5

Map2k5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Map2k5 Q9WVS7 Map3k2 Mus musculus Q61083
Pull Down
12912994
Intra
Map2k5 Q9WVS7 Map3k2 Mus musculus Q61083
CoIP
12912994
Intra
Map2k5 Q9WVS7 Map3k3 Mus musculus Q61084
CoIP
12912994
Intra
Map2k5 Q9WVS7 Map3k3 Mus musculus Q61084
Y2H
15102471
Intra
Map2k5 Q9WVS7 Map3k3 Mus musculus Q61084
Pull Down
12912994
Intra
Map2k5 Q9WVS7 Sqstm1 Mus musculus Q64337
Y2H
15102471
Intra
Map2k5 Q9WVS7 Nap1l1 Mus musculus P28656
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08041 MAP2K5 Human Pre-designed siRNA Set A / Unkown
HY-RS08042 Map2k5 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08043 Map2k5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k5 NCBI NCBI:5607