MYCL - MYCL proto-oncogene, bHLH transcription factor Gene

Also Known as LMYC; L-Myc; MYCL1; bHLHe38

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4610

About MYCL

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,895,428-39,901,917 (from NCBI)

This gene has 4 transcripts (splice variants), 270 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in skin (RPKM 18.4), pancreas (RPKM 11.3) and 17 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Located in chromosome and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MYCL Products (3)

mRNA Protein Name
NM_001033081.3 NP_001028253.1 protein L-Myc isoform 1
NM_001033082.3 NP_001028254.2 protein L-Myc isoform 3
NM_005376.5 NP_005367.2 protein L-Myc isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYCL Protein Structure

Myc_N

Myc_N: Myc amino-terminal region (28 - 167)

Myc_N

Myc_N: Myc amino-terminal region (187 - 251)

HLH

HLH: Helix-loop-helix DNA-binding domain (312 - 363)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
Protein Preferred Names Protein Names

protein L-Myc

  • class E basic helix-loop-helix protein 38

Related Diseases

Diseases Alias
Apocrine Adenosis Of Breast

  • Apocrine Adenosis Of The Breast
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Lower Lip Cancer
Small Cell Cancer Of The Lung

  • Small Cell Lung Cancer

  • Small Cell Lung Carcinoma

  • Sclc

  • Small-Cell Cancer Of Lung

  • Lung Small Cell Carcinoma

  • Sclc1

  • Sccl

  • Cancer, Lung, Small Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Cerebral Primitive Neuroectodermal Tumor

  • Pnet Of Cerebrum
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08883 MYCL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20778 Mycl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27292 Mycl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MYCL VGNC VGNC:43529
Bos taurus MYCL VGNC VGNC:31787
Felis catus MYCL VGNC VGNC:80286
Rattus norvegicus MYCL RGD RGD:1588591
Macaca mulatta MYCL VGNC VGNC:100016
Mus musculus MYCL MGD MGI:96799
Others MYCL NCBI