P2RY2 - purinergic receptor P2Y2 Gene

Also Known as P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5029

About P2RY2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:73,218,281-73,242,427 (from NCBI)

This gene has 3 transcripts (splice variants), 201 orthologues and 15 paralogues. Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues.

Summary

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some Cancer cell types. It is involved in many cellular functions, such as proliferation, Apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

P2RY2 Products (3)

mRNA Protein Name
NM_176071.3 NP_788085.3 P2Y purinoceptor 2
NM_002564.4 NP_002555.4 P2Y purinoceptor 2
NM_176072.3 NP_788086.3 P2Y purinoceptor 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (51 - 306)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 2

  • ATP receptor

  • P2U nucleotide receptor

  • P2U purinoceptor 1

  • P2U receptor 1

  • purinergic receptor P2Y, G-protein coupled, 2

  • purinoceptor P2Y2

Related Diseases

Diseases Alias
Accommodative Spasm

  • Spasm Of Accommodation

  • Cyclospasm

  • Ciliary Muscle Spasm

  • Ciliary Body Spasm
Dry Eye Syndrome

  • Dry Eye Syndromes

  • Dry Eye Disease

  • Tear Film Insufficiency

  • Xerophthalmia
Conjunctivochalasis
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Lacrimal Apparatus Disease

  • Lacrimal Apparatus Diseases
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09928 P2RY2 Human Pre-designed siRNA Set A / Unkown
HY-RS09929 P2ry2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09930 P2ry2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris P2RY2 VGNC VGNC:44217
Felis catus P2RY2 VGNC VGNC:81965
Bos taurus P2RY2 VGNC VGNC:32528
Rattus norvegicus P2RY2 RGD RGD:62088
Mus musculus P2RY2 MGD MGI:105107
Macaca mulatta P2RY2 VGNC VGNC:75738
Others P2RY2 NCBI